Ulcerative colitis:: Female fecundity before diagnosis, during disease, and after surgery compared with a population sample

被引:181
作者
Olsen, KO
Juul, S
Berndtsson, I
Öresland, T
Laurberg, S
机构
[1] Aarhus Univ Hosp, Surg Dept L, Sect AAS, DK-8000 Aarhus, Denmark
[2] Univ Aarhus, Dept Epidemiol & Social Med, Aarhus, Denmark
[3] Sahlgrens Univ Hosp, Colorectal Unit, Gothenburg, Sweden
关键词
D O I
10.1053/gast.2002.30345
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background & Aims: Women with ulcerative colitis generally have normal fertility. The aim of this study was to compare patients' fecundability before and after restorative proctocolectomy with ileal pouch-anal anastomosis with the fecundability of the general population. Methods: Historical follow-up was performed on 343 consecutive female patients aged :10.6-40.5 years at surgery and a reference population of 1200 women aged 25-40 years. A total of 290 (85%) patients and 661 (55%) women in the reference population agreed to participate in a structured telephone interview concerning reproductive behavior and waiting times to pregnancy. Cox regression and Kaplan-Meier plots were used for analysis. Results: Surgery significantly reduced the ratio of patient to reference population fecundability, which decreased to 0.20 (P < 0.0001). Before diagnosis and from diagnosis until colectomy, the fecundability of the patients was similar to that of the reference population. Conclusions: Female patients with ulcerative colitis have normal fecundity before surgical treatment. Surgery severely reduces female fecundity. Information about this reduction in fecundity should be given before surgery, and if a woman has an unfulfilled wish for pregnancy after surgery, early referral to a gynecologist is recommended.
引用
收藏
页码:15 / 19
页数:5
相关论文
共 24 条
[1]   Fertility patterns after appendicectomy:: historical cohort study [J].
Andersson, R ;
Lambe, M ;
Bergström, R .
BRITISH MEDICAL JOURNAL, 1999, 318 (7189) :963-967
[2]   A QUALITY STUDY OF A MEDICAL BIRTH REGISTRY [J].
CNATTINGIUS, S ;
ERICSON, A ;
GUNNARSKOG, J ;
KALLEN, B .
SCANDINAVIAN JOURNAL OF SOCIAL MEDICINE, 1990, 18 (02) :143-148
[3]   FERTILITY AND SEXUAL AND GYNECOLOGIC FUNCTION AFTER ILEAL POUCH-ANAL ANASTOMOSIS [J].
COUNIHAN, TC ;
ROBERTS, PL ;
SCHOETZ, DJ ;
COLLER, JA ;
MURRAY, JJ ;
VEIDENHEIMER, MC .
DISEASES OF THE COLON & RECTUM, 1994, 37 (11) :1126-1129
[4]  
JAMEROT G, 1982, SCAND J GASTROENTERO, V17, P1
[5]  
JOFFE M, 1993, FERTIL STERIL, V60, P99
[6]   A TIME TO PREGNANCY QUESTIONNAIRE DESIGNED FOR LONG-TERM RECALL - VALIDITY IN OXFORD, ENGLAND [J].
JOFFE, M ;
VILLARD, L ;
LI, ZM ;
PLOWMAN, R ;
VESSEY, M .
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 1995, 49 (03) :314-319
[7]   ILEAL POUCH-ANAL ANASTOMOSIS FUNCTION FOLLOWING CHILDBIRTH - AN EXTENDED EVALUATION [J].
JUHASZ, ES ;
FOZARD, B ;
DOZOIS, RR ;
ILSTRUP, DM ;
NELSON, H .
DISEASES OF THE COLON & RECTUM, 1995, 38 (02) :159-165
[8]   Regional differences in waiting time to pregnancy: pregnancy-based surveys from Denmark, France, Germany, Italy and Sweden [J].
Juul, S ;
Karmaus, W ;
Olsen, J .
HUMAN REPRODUCTION, 1999, 14 (05) :1250-1254
[9]   Infertility and subfecundity in population-based samples from Denmark, Germany, Italy, Poland and Spain [J].
Karmaus, W ;
Juul, S .
EUROPEAN JOURNAL OF PUBLIC HEALTH, 1999, 9 (03) :229-235
[10]  
Knudsen LB, 1998, DAN MED BULL, V45, P320