Serum IgG antibodies to human herpesvirus-6 (HHV-6) do not predict the progression of HIV disease to AIDS

被引:7
作者
Dorrucci, M [1 ]
Rezza, C [1 ]
Andreoni, M [1 ]
Pezzotti, P [1 ]
Nicastri, E [1 ]
Ventura, L [1 ]
Zignani, M [1 ]
Alliegro, MB [1 ]
Tarantini, G [1 ]
Salassa, B [1 ]
Colangeli, V [1 ]
Mazzarello, G [1 ]
Ursitti, MA [1 ]
Barbanera, M [1 ]
Pristerà, R [1 ]
Castelli, F [1 ]
Ortona, L [1 ]
机构
[1] Ist Super Sanita, Ctr Operat AIDS, Epidemiol & Biostat Lab, I-00161 Rome, Italy
关键词
AIDS progression; HIV-1; IgG HHV-6 antibodies;
D O I
10.1023/A:1007503018729
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Objectives: To evaluate if different levels of human herpesvirus 6 (HHV-6) antibodies can predict HIV disease progression. Design: Longitudinal study of individuals with a documented date of HIV seroconversion. Setting: Clinical centers located throughout Italy. Patients: Individuals who serconverted for HIV between 1983 and 1995 in Italy. Methods: Sera were tested for IgG antibodies to HHV-6 using a commercial enzyme immunoassay, A serum sample with an optical density (OD) greater than or equal to 242 (i.e. the mean value of 10 negative controls + 4 x standard deviation) was considered as HHV-6 positive; the progression of HIV disease was evaluated estimating the relative hazards (RH) of AIDS (by Cox models) for individuals with higher levels vs, lower levels of HHV-6 antibodies or considering levels of antibodies based on 10% increase of the distribution (deciles). Rates of CD4 decline fitting linear regression were also estimated, Results: A total of 381 persons were followed for a median time of 4 years (range: 0.15-9 years) following the date of collection of the serum sample. The median OD value of HHV-6 antibodies was 306, with an interquartile range of 241-440 and a range of 48-2330. A slight inverse correlation was found between HHV-6 antibody levels and age of the individual at the time of serum collection (Spearman rank correlation coefficient, -0.16; p = 0.0013). No association was found between HHV-6 and CD4 level or between HHV-6 and CD8 level at the date of serum collection. The unadjusted RH of progression to AIDS was 0.63 (95% CI: 0.42-0.96) for HHV-6 positive individuals vs. HHV-6 negative; when adjusting for possible confounders (CD4, age, pre-AIDS HIV-related pathologies at the date of sera collection,and previous anti-herpes treatment), the RH of AIDS increased to 0.80 (95% CI: 0.51-1.23). No particular association with HIV disease progression was found when using the deciles of the distribution of HHV-6 antibodies. The median CD4 cell loss was 5.0 x 10(6) cells/l per month among HHV-6 positive individuals and 5.7 x 10(6) cells/l per month among the others. Conclusions: The presence of high levels of HHV-6 antibodies does not seem to predict the clinical or immunologic progression of HIV disease.
引用
收藏
页码:317 / 322
页数:6
相关论文
共 16 条
  • [1] ANCELLEPARK R, 1993, LANCET, P341
  • [2] BALSQUEZ MV, 1995, J ACQ IMMUN DEF SYND, V9, P389
  • [3] BROWN NA, 1988, LANCET, V2, P396
  • [4] Variant A human herpesvirus six as a cofactor in the pathogenesis of AIDS
    Carrigan, DR
    Harrington, D
    Knox, KK
    [J]. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1996, 13 (01): : 97 - 98
  • [5] CERMELLI C, 1992, MICROBIOLOGICA, V15, P57
  • [6] CHEN H, 1992, EUR J EPIDEMIOL, V8, P217, DOI 10.1007/BF00144803
  • [7] HUMAN HERPES VIRUS-6 INCREASES HIV-1 EXPRESSION IN CO-INFECTED T-CELLS VIA NUCLEAR FACTORS BINDING TO THE HIV-1 ENHANCER
    ENSOLI, B
    LUSSO, P
    SCHACHTER, F
    JOSEPHS, SF
    RAPPAPORT, J
    NEGRO, F
    GALLO, RC
    WONGSTAAL, F
    [J]. EMBO JOURNAL, 1989, 8 (10) : 3019 - 3027
  • [8] Lee E. T., 1992, Statistical Methods for Survival Data Analysis, V2nd
  • [9] HUMAN HERPESVIRUS-6 IN AIDS
    LUSSO, P
    GALLO, RC
    [J]. LANCET, 1994, 343 (8897) : 555 - 556
  • [10] INDUCTION OF CD4 AND SUSCEPTIBILITY TO HIV-1 INFECTION IN HUMAN CD8+ LYMPHOCYTES-T BY HUMAN HERPESVIRUS-6
    LUSSO, P
    DEMARIA, A
    MALNATI, M
    LORI, F
    DEROCCO, SE
    BASELER, M
    GALLO, RC
    [J]. NATURE, 1991, 349 (6309) : 533 - 535