Vicarious trial-and-error behavior and hippocampal cytochrome oxidase activity during Y-maze discrimination learning in the rat

被引:32
作者
Hu, D
Xu, XJ
Gonzalez-Lima, F
机构
[1] MIT, McGovern Inst Brain Res, Cambridge, MA 02139 USA
[2] Grand Valley State Univ, Dept Psychol, Allendale, MI 49401 USA
[3] Univ Texas, Dept Psychol, Austin, TX 78712 USA
[4] Univ Texas, Inst Neurosci, Austin, TX 78712 USA
关键词
CA1; CA2; cytochrome oxidase; dentate gyrus; discrimination learning; vicarious trial-and-error (VTE);
D O I
10.1080/00207450500403108
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The present study investigated whether more vicarious trial-and-error (VTE) behavior, defined by head movement from one stimulus to another at a choice point during simultaneous discriminations, led to better visual discrimination learning in a Y-maze, and whether VTE behavior was a function of the hippocampus by measuring regional brain cytochrome oxidase (C.O.) activity, an index of neuronal metabolic activity. The results showed that the more VTEs a rat made, the better the rat learned the visual discrimination. Furthermore, both learning and VTE behavior during learning were correlated to C.O. activity in the hippocampus, suggesting that the hippocampus plays a role in VTE behavior during discrimination learning.
引用
收藏
页码:265 / 280
页数:16
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