A versatile synthesis of 2-haloalk-2(Z)-en-1-ols and 1-chloro-1(Z)-alkenes from trichloromethylcarbinols

被引：18

作者：

Baati, R

Barma, DK

Falck, JR

Mioskowski, C ^{[1
]}

机构：

[1] SW Texas State Univ, Med Ctr, Dept Biochem, Dallas, TX 75390 USA

[2] Univ Strasbourg 1, Fac Pharm, Lab Synth Bio Organ, UMR 7514, F-67401 Illkirch Graffenstaden, France

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(02)00210-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

CrCl2 converts trichloromethylcarbinols under mild conditions to (E)-alpha-haloalkylidene chromium carbenoids which add to aldehydes or are quenched with water affording 2-haloalk-2(Z)-en-1-ols and 1-chloro-1(Z)-alkenes, respectively, in high yield. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

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页码：2183 / 2185

页数：3

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