Tailored IPN Hydrogel Bead of Sodium Carboxymethyl Cellulose and Sodium Carboxymethyl Xanthan Gum for Controlled Delivery of Diclofenac Sodium

被引：58

作者：

Bhattacharya, Shiv Sankar ^{[1
]}

Shukla, Seema ^{[1
]}

Banerjee, Subham

Chowdhury, Purojit ^{[1
]}

Chakraborty, Prithviraj ^{[2
]}

Ghosh, Amitava ^{[2
]}

机构：

[1] IFTM Univ, Sch Pharmaceut Sci, Moradabad 244001, Uttar Pradesh, India

[2] Bengal Coll Pharmaceut Sci & Res, Durgapur, W Bengal, India

来源：

POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING | 2013年 / 52卷 / 08期

关键词：

Controlled release; Emulsion gelation method; IPN bead; Sodium carboxymethyl xanthan; CONTROLLED-RELEASE; DRUG-DELIVERY; IN-VITRO; ETHYL CELLULOSE; CROSS-LINKING; GUAR GUM; MICROSPHERES; POLYMER; HYDROCHLORIDE; MICROBEADS;

D O I：

10.1080/03602559.2013.763361

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

Interpenetrating network (IPN) beads of sodium carboxymethyl cellulose (SCMC) and sodium carboxymethyl xanthan (SCMX) containing diclofenac sodium (DS), a non steroidal anti-inflammatory drug were prepared by single water-in-water (w/w) emulsion gelation process using AlCl3 as the cross-linking agent. The influence of different formulation variables like polymer ratio, gelation time, concentration of cross-linking agenton in-vitro physico-chemical parameters and drug release studies were performed. The tailored IPN bead were analytically evaluated by Scanning electron microscopy (SEM), Fourier Transform Infra-red (FTIR), X-ray diffraction (XRD), Differential Scanning Calorimetry (DSC) analysis. IPN beads showed improved drug encapsulation efficiency along with enhanced intestinal drug release.

引用

页码：795 / 805

页数：11

共 30 条

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Fabrication and assessment of polyacrylate/(guar gum modified bentonite) superabsorbent polymeric composite [J].