The anti-aging effects of Ludwigia octovalvis on Drosophila melanogaster and SAMP8 mice

被引:46
作者
Lin, Wei-Sheng [1 ]
Chen, Jun-Yi [2 ]
Wang, Jo-Chiao [1 ]
Chen, Liang-Yu [3 ]
Lin, Che-Hao [4 ]
Hsieh, Tsung-Ren [4 ]
Wang, Ming-Fu [5 ]
Fu, Tsai-Feng [6 ]
Wang, Pei-Yu [1 ]
机构
[1] Natl Taiwan Univ, Coll Med, Grad Inst Brain & Mind Sci, Taipei 10051, Taiwan
[2] Natl Chengchi Univ, Inst Neurosci, Taipei 11623, Taiwan
[3] Mingchuan Univ, Dept Biotechnol, Tao Yuan, Taiwan
[4] Hsiehyu Biotech Co Ltd, Taipei, Taiwan
[5] Providence Univ, Dept Food & Nutr, Taichung, Taiwan
[6] Natl Chinan Univ, Dept Appl Chem, Nantou, Taiwan
关键词
Ludwigia octovalvis; Dietary restriction; Lifespan; AMPK; ELEVATED T-MAZE; ACCELERATED MOUSE SAM; AGE-RELATED-CHANGES; LIFE-SPAN; CALORIE RESTRICTION; DIETARY RESTRICTION; C-ELEGANS; RHESUS-MONKEYS; MITOCHONDRIAL BIOGENESIS; SACCHAROMYCES-CEREVISIAE;
D O I
10.1007/s11357-013-9606-z
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
030301 [社会学]; 100201 [内科学];
摘要
We investigated the anti-aging effects of Ludwigia octovalvis (Jacq.) P. H. Raven (Onagraceae), an extract of which is widely consumed as a healthful drink in a number of countries. Using the fruit fly, Drosophila melanogaster, as a model organism, we demonstrated that L. octovalvis extract (LOE) significantly extended fly lifespan on a high, but not a low, calorie diet, indicating that LOE may regulate lifespan through a dietary restriction (DR)-related pathway. LOE also attenuated age-related cognitive decline in both flies and in the senescence-accelerated-prone 8 (SAMP8) mouse, without causing any discernable negative trade-offs, including water intake, food intake, fecundity, or spontaneous motor activity. LOE contained high levels of polyphenols and flavonoids, which possess strong DPPH radical scavenging activity, and was shown to attenuate paraquat-induced oxidative damage and lethality in flies. Gas chromatography-mass spectrometry (GC-MS) analyses identified 17 known molecules, of which beta-sitosterol and squalene were the two most abundant. We further demonstrated that beta-sitosterol was capable of extending lifespan, likely through activating AMP-activated protein kinase (AMPK) in the fat body of adult flies. Taken together, our data suggest that LOE is a potent anti-aging intervention with potential for treating age-related disorders.
引用
收藏
页码:689 / 703
页数:15
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