Production of neuroprotective NGF in astrocyte-T helper cell cocultures is upregulated following antigen recognition

被引：8

作者：

Oren, A

Falk, K

Rötzschke, O

Bechmann, I

Nitsch, R

Gimsa, U

机构：

[1] Univ Rostock, Dept Neurol, D-18147 Rostock, Germany

[2] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany

[3] Humboldt Univ, Inst Anat, Dept Cell & Neurobiol, D-10098 Berlin, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2004年 / 149卷 / 1-2期

关键词：

Th1; Th2; growth factors; neurotrophins; mouse;

D O I：

10.1016/j.jneuroim.2003.12.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Astrocytic production of nerve growth factor (NGF) is increased during inflammation of the central nervous system (CNS). Here we show that cell-cell interaction between primary murine astrocytes and myelin basic protein (MBP)-specific T cell receptor (TCR) transgenic Th1 and Th2 cells significantly increased production of NGF. This upregulation was found to be dependent on antigen recognition. Neutralization of cytokines produced in cocultures did not affect NGF production. This novel finding suggests a neuroprotective role of astrocytes during T cell-mediated inflammation in the CNS. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：59 / 65

页数：7

共 28 条

[1]

Aloisi F, 1999, EUR J IMMUNOL, V29, P2705, DOI 10.1002/(SICI)1521-4141(199909)29:09<2705::AID-IMMU2705>3.0.CO

[2]

2-1

[3]

Aloisi F, 1998, J IMMUNOL, V160, P4671

[4]

Arredondo LR, 2001, EUR J IMMUNOL, V31, P625