Telomeres and telomerase biology in vertebrates: Progress towards a non-human model for replicative senescence and ageing

被引：37

作者：

Davis, T ^{[1
]}

Kipling, D ^{[1
]}

机构：

[1] Cardiff Univ, Sch Med, Dept Pathol, Cardiff, Wales

来源：

BIOGERONTOLOGY | 2005年 / 6卷 / 06期

基金：

英国生物技术与生命科学研究理事会;

关键词：

cellular immortalisation; hTERT; p21(WAF1); p53; primates; sheep; tumourigenesis;

D O I：

10.1007/s10522-005-4901-4

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Studies on telomere and telomerase biology are fundamental to the understanding of human ageing and age-related diseases such as cancer. However, human studies of whole body ageing are hampered by the lack of suitable fully reflective animal model systems, the wild-type mouse model being unsuitable due to differences in telomere biology. Here we summarise recent data on the biology of telomeres, telomerase, and the tumour suppressor protein p53 in various animals, and examine their possible roles in replicative senescence, ageing, and tumourigenesis. The advantages and disadvantages of various animals as model systems for whole body ageing in humans are discussed.

引用

收藏

页码：371 / 385

页数：15

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