Apoptosis: Letting slip the dogs of war

被引:42
作者
Wolf, BB [1 ]
Green, DR [1 ]
机构
[1] La Jolla Inst Allergy & Immunol, Dept Cellular Immunol, San Diego, CA 92121 USA
关键词
D O I
10.1016/S0960-9822(02)00736-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent studies have shown that, during cell death, the protein Omi is released from the mitochondrial intermembrane space into the cytosol, where it augments caspase-dependent apoptosis by blocking inhibitors and may induce caspase-independent cell death via its serine protease activity.
引用
收藏
页码:R177 / R179
页数:3
相关论文
共 20 条
[1]   An emerging blueprint for apoptosis in Drosophila [J].
Abrams, JM .
TRENDS IN CELL BIOLOGY, 1999, 9 (11) :435-440
[2]   Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition [J].
Du, CY ;
Fang, M ;
Li, YC ;
Li, L ;
Wang, XD .
CELL, 2000, 102 (01) :33-42
[3]   Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia [J].
Faccio, L ;
Fusco, C ;
Chen, A ;
Martinotti, S ;
Bonventre, JV ;
Zervos, AS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (04) :2581-2588
[4]   Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function [J].
Goyal, L ;
McCall, K ;
Agapite, J ;
Hartwieg, E ;
Steller, H .
EMBO JOURNAL, 2000, 19 (04) :589-597
[5]   Apoptotic pathways: Paper wraps stone blunts scissors [J].
Green, DR .
CELL, 2000, 102 (01) :1-4
[6]  
HEGDE R, 2001, IN PRESS J BIOL CHEM
[7]   A functional role for death proteases in s-Myc- and c-Myc-mediated apoptosis [J].
Kagaya, S ;
Kitanaka, C ;
Noguchi, I ;
Mochizuki, T ;
Sugiyama, A ;
Asai, A ;
Yasuhara, N ;
Eguchi, Y ;
Tsujimoto, Y ;
Kuchino, Y .
MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (11) :6736-6745
[8]  
MARTINS LM, 2001, IN PRESS J BIOL CHEM
[9]   The inhibitor of apoptosis protein-binding domain of Smac is not essential for its proapoptotic activity [J].
Roberts, DL ;
Merrison, W ;
MacFarlane, M ;
Cohen, GM .
JOURNAL OF CELL BIOLOGY, 2001, 153 (01) :221-227
[10]   Two CD95 (APO-1/Fas) signaling pathways [J].
Scaffidi, C ;
Fulda, S ;
Srinivasan, A ;
Friesen, C ;
Li, F ;
Tomaselli, KJ ;
Debatin, KM ;
Krammer, PH ;
Peter, ME .
EMBO JOURNAL, 1998, 17 (06) :1675-1687