Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli

被引：617

作者：

Ungless, MA ^{[1
]}

Magill, PJ ^{[1
]}

Bolam, JP ^{[1
]}

机构：

[1] Univ Oxford, Dept Pharmacol, MRC, Anat Neuropharmacol Unit, Oxford OX1 3TH, England

来源：

SCIENCE | 2004年 / 303卷 / 5666期

关键词：

D O I：

10.1126/science.1093360

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Dopamine neurons play a key role in reward-related behaviors. Reward coding theories predict that dopamine neurons will be inhibited by or will not respond to aversive stimuli. Paradoxically, between 3 and 49% of presumed dopamine neurons are excited by aversive stimuli. We found that, in the ventral tegmental area of anesthetized rats, the population of presumed dopamine neurons that are excited by aversive stimuli is actually not dopaminergic. The identified dopamine neurons were inhibited by the aversive stimulus. These findings suggest that dopamine neurons are specifically excited by reward and that a population of nondopamine neurons is excited by aversive stimuli.

引用

页码：2040 / 2042

页数：3

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