Antimicrobial Organometallic Dendrimers with Tunable Activity against Multidrug-Resistant Bacteria

被引：62

作者：

Abd-El-Aziz, Alaa S. ^{[1
]}

Agatemor, Christian ^{[1
]}

Etkin, Nola ^{[1
]}

Overy, David P. ^{[1
,2
]}

Lanteigne, Martin ^{[1
]}

McQuillan, Katherine ^{[1
]}

Kerr, Russell G. ^{[1
,3
]}

机构：

[1] Univ Prince Edward Isl, Dept Chem, Charlottetown, PE C1A 4P3, Canada

[2] Univ Prince Edward Isl, Atlantic Vet Coll, Dept Pathol & Microbiol, Charlottetown, PE C1A 4P3, Canada

[3] Univ Prince Edward Isl, Atlantic Vet Coll, Dept Biomed Sci, Charlottetown, PE C1A 4P3, Canada

来源：

BIOMACROMOLECULES | 2015年 / 16卷 / 11期

基金：

加拿大自然科学与工程研究理事会;

关键词：

SUBSTITUTED ARENECYCLOPENTADIENYLIRON CATIONS; TRANSITION-METALS; ANTIBACTERIAL AGENTS; DIENYL COMPLEXES; ETA-5-CYCLOPENTADIENYLIRON HEXAFLUOROPHOSPHATES; ELECTROCHEMICAL REDUCTION; BEHAVIOR; POLYMERS; HYDRIDE; POLYELECTROLYTES;

D O I：

10.1021/acs.biomac.5b01207

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Multidrug-resistant pathogens are an increasing threat to public health. In an effort to curb the virulence of these pathogens, new antimicrobial agents are sought. Here we report a new class of antimicrobial organometallic dendrimers with tunable activity against multidrug-resistant Gram-positive bacteria that included methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. Mechanistically, these redox-active, cationic organometallic dendrimers induced oxidative stress on bacteria and also disrupted the microbial cell membrane. The minimum inhibitory concentrations, which provide a quantitative measure of the antimicrobial activity of these dendrimers, were in the low micromolar range. AlamarBlue cell viability assay also confirms the antimicrobial activity of these dendrimers. Interestingly, these dendrimers were noncytotoxic to epidermal cell lines and to mammalian red blood cells, making them potential antimicrobial platforms for topical applications.

引用

页码：3694 / 3703

页数：10

共 58 条

[1]

Abd-El-Aziz A. S., 2015, CHEM PHYS, V216, P369

[2]

SOLVENT AND TEMPERATURE EFFECTS ON THE ELECTROCHEMICAL REDUCTION OF SOME ETA-5-CYCLOPENTADIENYLIRON HEXAFLUOROPHOSPHATES OF ETA-6-POLYCYCLIC AND ETA-6-HETEROCYCLIC COMPLEXES [J].

ABDELAZIZ, AS ;

WINKLER, K ;

BARANSKI, AS .

INORGANICA CHIMICA ACTA, 1992, 194 (02) :207-212

[3]

ELECTROCHEMICAL STUDIES OF ETA-5-CYCLOPENTADIENYLIRON HEXAFLUOROPHOSPHATES OF ETA-6-SUBSTITUTED ARENES AND ETA-6-HETEROCYCLES [J].

ABDELAZIZ, AS ;

BARANSKI, AS ;

PIORKO, A ;

SUTHERLAND, RG .

INORGANICA CHIMICA ACTA, 1988, 147 (01) :77-85

[4]

Effect of ligand structure, solvent, and temperature on the electrochemical behavior of polyarene-iron complexes [J].

AbdElAziz, AS ;

deDenus, CR ;

Epp, KM ;

Smith, S ;

Jaeger, RJ ;

Pierce, DT .

CANADIAN JOURNAL OF CHEMISTRY, 1996, 74 (05) :650-657

[5]

Protective role of curcumin in nephrotoxic oxidative damage induced by vancomycin in rats [J].

Ahmida, Mohamed H. S. .

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 2012, 64 (03) :149-153

[6]

[Anonymous], M7A6 NAT COMM CLIN L

[7]

[Anonymous], 2012, Int. Scholarly Res. Not, DOI DOI 10.5402/2012/195727

[8]

Dendritic glycopolymers based on dendritic polyamine scaffolds: view on their synthetic approaches, characteristics and potential for biomedical applications [J].

Appelhans, Dietmar ;

Klajnert-Maculewicz, Barbara ;

Janaszewska, Anna ;

Lazniewska, Joanna ;

Voit, Brigitte .

CHEMICAL SOCIETY REVIEWS, 2015, 44 (12) :3968-3996

[9]

ORGANO-METALLIC ELECTRON RESERVOIRS .5. A NOVEL MODE OF C-H ACTIVATION USING DIOXYGEN VIA SUPEROXIDE RADICAL-ANION IN SOLUTION AND IN THE SOLID-STATE WITH C5R5FEIC6R' 6 - SUBSEQUENT BOND FORMATION WITH C, SI, P, MN, FE, CR, MO, AND HALOGENS [J].

ASTRUC, D ;

HAMON, JR ;

ROMAN, E ;

MICHAUD, P .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (25) :7502-7514

[10]

ASTRUC D, 1969, CR ACAD SCI C CHIM, V269, P608

← 1 2 3 4 5 6 →