Viral Perturbations of Host Networks Reflect Disease Etiology

被引：88

作者：

Gulbahce, Natali ^{[1
,2
,3
,4
]}

Yan, Han ^{[3
,4
,5
]}

Dricot, Amelie ^{[3
,4
,5
]}

Padi, Megha ^{[4
,6
,7
]}

Byrdsong, Danielle ^{[3
,4
,5
]}

Franchi, Rachel ^{[3
,4
,5
,8
]}

Lee, Deok-Sun ^{[1
,2
,9
,10
]}

Rozenblatt-Rosen, Orit ^{[11
,18
]}

Mar, Jessica C. ^{[4
,6
,7
]}

Calderwood, Michael A. ^{[3
,4
,12
,13
]}

Baldwin, Amy ^{[12
,13
]}

Zhao, Bo ^{[12
,13
]}

Santhanam, Balaji ^{[3
,4
,5
]}

Braun, Pascal ^{[3
,4
,5
]}

Simonis, Nicolas ^{[3
,4
,5
]}

Huh, Kyung-Won ^{[12
,13
]}

Hellner, Karin ^{[12
,13
]}

Grace, Miranda ^{[12
,13
]}

Chen, Alyce ^{[12
,13
]}

Rubio, Renee ^{[4
,6
,7
]}

Marto, Jarrod A. ^{[4
,14
]}

Christakis, Nicholas A. ^{[15
,16
]}

Kieff, Elliott ^{[12
,13
]}

Roth, Frederick P. ^{[3
,4
,17
]}

Roecklein-Canfield, Jennifer ^{[3
,4
,5
,8
]}

DeCaprio, James A. ^{[11
,18
]}

Cusick, Michael E. ^{[3
,4
,5
]}

Quackenbush, John ^{[4
,6
,7
]}

Hill, David E. ^{[3
,4
,5
]}

Muenger, Karl ^{[12
,13
]}

Vidal, Marc ^{[3
,4
,5
]}

Barabasi, Albert-Laszlo ^{[1
,2
,3
,4
,18
]}

机构：

[1] Northeastern Univ, CCNR, Boston, MA 02115 USA

[2] Northeastern Univ, Dept Phys, Boston, MA 02115 USA

[3] Dana Farber Canc Inst, CCSB, Boston, MA 02115 USA

[4] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Dept Genet, Boston, MA USA

[6] Dana Farber Canc Inst, CCCB, Dept Biostat & Computat Biol, Boston, MA 02115 USA

[7] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[8] Simmons Coll, Dept Chem, Boston, MA 02115 USA

[9] Inha Univ, Dept Nat Med Sci, Inchon, South Korea

[10] Inha Univ, Dept Phys, Inchon, South Korea

[11] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[12] Brigham & Womens Hosp, Channing Lab, Div Infect Dis, Boston, MA 02115 USA

[13] Harvard Univ, Sch Med, Dept Med, Boston, MA USA

[14] Dana Farber Canc Inst, Blais Prote Ctr, Boston, MA 02115 USA

[15] Harvard Univ, Sch Med, Dept Hlth Care Policy, Cambridge, MA 02138 USA

[16] Harvard Univ, Dept Sociol, Cambridge, MA 02138 USA

[17] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[18] Harvard Univ, Brigham & Womens Hosp, Dept Med, Sch Med, Boston, MA 02115 USA

来源：

PLOS COMPUTATIONAL BIOLOGY | 2012年 / 8卷 / 06期

基金：

美国国家卫生研究院; 新加坡国家研究基金会;

关键词：

EPSTEIN-BARR-VIRUS; TYPE-16; E7; ONCOPROTEIN; HUMAN-PAPILLOMAVIRUS; BIOLOGY; GENE; ASSOCIATION; EXPRESSION; RESOURCE; PLATFORM; HEAD;

D O I：

10.1371/journal.pcbi.1002531

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Many human diseases, arising from mutations of disease susceptibility genes (genetic diseases), are also associated with viral infections (virally implicated diseases), either in a directly causal manner or by indirect associations. Here we examine whether viral perturbations of host interactome may underlie such virally implicated disease relationships. Using as models two different human viruses, Epstein-Barr virus (EBV) and human papillomavirus (HPV), we find that host targets of viral proteins reside in network proximity to products of disease susceptibility genes. Expression changes in virally implicated disease tissues and comorbidity patterns cluster significantly in the network vicinity of viral targets. The topological proximity found between cellular targets of viral proteins and disease genes was exploited to uncover a novel pathway linking HPV to Fanconi anemia.

引用

页数：10

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[1]

McKusick's Online Mendelian Inheritance in Man (OMIM®) [J].