Adult Stem Cell Therapy for Stroke: Challenges and Progress

被引：90

作者：

Bang, Oh Young ^{[1
,2
]}

Kim, Eun Hee ^{[2
]}

Cha, Jae Min ^{[3
,4
]}

Moon, Gyeong Joon ^{[2
,5
]}

机构：

[1] Sungkyunkwan Univ, Dept Neurol, Samsung Med Ctr, Sch Med, Seoul, South Korea

[2] Samsung Med Ctr, Translat & Stem Cell Res Lab Stroke, Seoul, South Korea

[3] Samsung Elect Co Ltd, Samsung Adv Inst Technol, Samsung Biomed Res Inst, Seoul, South Korea

[4] Samsung Med Ctr, Res Inst Future Med, Med Device Res Ctr, Seoul, South Korea

[5] Samsung Biomed Res Inst, Stem Cell & Regenerat Med Inst, Seoul, South Korea

来源：

JOURNAL OF STROKE | 2016年 / 18卷 / 03期

关键词：

Stroke; Biomaterials; Stem cells; Mesenchymal stem cells; MESENCHYMAL STROMAL CELLS; MARROW MONONUCLEAR-CELLS; PROMOTE FUNCTIONAL RECOVERY; SCIATIC-NERVE REGENERATION; BONE-MARROW; ISCHEMIC-STROKE; CEREBRAL-ISCHEMIA; PROGENITOR CELLS; INDUCED NEUROGENESIS; INTRANASAL DELIVERY;

D O I：

10.5853/jos.2016.01263

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Stroke is one of the leading causes of death and physical disability among adults. It has been 15 years since clinical trials of stem cell therapy in patients with stroke have been conducted using adult stem cells like mesenchymal stem cells and bone marrow mononuclear cells. Results of randomized controlled trials showed that adult stem cell therapy was safe but its efficacy was modest, underscoring the need for new stem cell therapy strategies. The primary limitations of current stem cell therapies include (a) the limited source of engraftable stem cells, (b) the presence of optimal time window for stem cell therapies, (c) inherited limitation of stem cells in terms of growth, trophic support, and differentiation potential, and (d) possible transplanted cell-mediated adverse effects, such as tumor formation. Here, we discuss recent advances that overcome these hurdles in adult stem cell therapy for stroke.

引用

页码：256 / 266

页数：11

共 113 条

[1]

Intravenous Bone Marrow Stem Cell Grafts Preferentially Migrate to Spleen and Abrogate Chronic Inflammation in Stroke [J].

Acosta, Sandra A. ;

Tajiri, Naoki ;

Hoover, Jaclyn ;

Kaneko, Yuji ;

Borlongan, Cesar V. .

STROKE, 2015, 46 (09) :2616-2627

[2]

Optical monitoring of stem cell-substratum interactions [J].

Aref, Amirreza ;

Horvath, Robert ;

McColl, James ;

Ramsden, Jeremy J. .

JOURNAL OF BIOMEDICAL OPTICS, 2009, 14 (01)

[3]

Asumda, Faizal Z. ;

Chase, P. Bryant .

BMC CELL BIOLOGY, 2011, 12

[4]

Clinical Trials of Adult Stem Cell Therapy in Patients with Ischemic Stroke [J].

Bang, Oh Young .

JOURNAL OF CLINICAL NEUROLOGY, 2016, 12 (01) :14-20

[5]

The Effect of CXCR4 Overexpression on Mesenchymal Stem Cell Transplantation in Ischemic Stroke [J].

Bang, Oh Young ;

Jin, Kyung Sil ;

Hwang, Mi Na ;

Kang, Ho Young ;

Kim, Byoung Joon ;

Lee, Sang Jin ;

Kang, Sangmee ;

Hwang, Yu Kyeong ;

Ahn, Jong Seong ;

Sung, Ki Woong .

CELL MEDICINE, 2012, 4 (02) :65-76

[6]

Autologous mesenchymal stem cell transplantation in stroke patients [J].

Bang, OY ;

Lee, JS ;

Lee, PH ;

Lee, G .

ANNALS OF NEUROLOGY, 2005, 57 (06) :874-882

[7]

Bang OY, 2015, 24 EUR STROK C VIENN

[8]

Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties [J].

Bartosh, Thomas J. ;

Ylostalo, Joni H. ;

Mohammadipoor, Arezoo ;

Bazhanov, Nikolay ;

Coble, Katie ;

Claypool, Kent ;

Lee, Ryang Hwa ;

Choi, Hosoon ;

Prockop, Darwin J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (31) :13724-13729

[9]

Battistella V, 2011, REGEN MED, V6, P45, DOI [10.2217/rme.10.97, 10.2217/RME.10.97]

[10]

A biodegradable fibrin scaffold for mesenchymal stem cell transplantation [J].

Bensaïd, W ;

Triffitt, JT ;

Blanchat, C ;

Oudina, K ;

Sedel, L ;

Petite, H .

BIOMATERIALS, 2003, 24 (14) :2497-2502

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