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NMR-guided fragment-based approach for the design of AAC(6′)-Ib ligands
被引:25
作者
:
Lombes, Thomas
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Paris 05, UMR 8638, CNRS, F-75006 Paris, France
Univ Paris 05, RMN Biol, CNRS, F-75006 Paris, France
Lombes, Thomas
[
2
]
Begis, Guillaume
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Paris 05, UMR 8638, CNRS, F-75006 Paris, France
Univ Paris 05, RMN Biol, CNRS, F-75006 Paris, France
Begis, Guillaume
[
2
]
Maurice, Frederique
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Paris 05, RMN Biol, CNRS, F-75006 Paris, France
Univ Paris 05, RMN Biol, CNRS, F-75006 Paris, France
Maurice, Frederique
[
1
]
Turcaud, Serge
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Paris 05, UMR 8638, CNRS, F-75006 Paris, France
Univ Paris 05, RMN Biol, CNRS, F-75006 Paris, France
Turcaud, Serge
[
2
]
Lecourt, Thomas
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Paris 05, UMR 8638, CNRS, F-75006 Paris, France
Univ Paris 05, RMN Biol, CNRS, F-75006 Paris, France
Lecourt, Thomas
[
2
]
Dardel, Frederic
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Paris 05, RMN Biol, CNRS, F-75006 Paris, France
Univ Paris 05, RMN Biol, CNRS, F-75006 Paris, France
Dardel, Frederic
[
1
]
论文数:
引用数:
h-index:
机构:
Micouin, Laurent
[
2
]
机构
:
[1]
Univ Paris 05, RMN Biol, CNRS, F-75006 Paris, France
[2]
Univ Paris 05, UMR 8638, CNRS, F-75006 Paris, France
来源
:
CHEMBIOCHEM
|
2008年
/ 9卷
/ 09期
关键词
:
aminoglycosides;
antibiotics;
coenzyme A;
fragment-based synthesis;
NMR spectroscopy;
D O I
:
10.1002/cbic.200700677
中图分类号
:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号
:
071010 ;
081704 ;
摘要
:
[No abstract available]
引用
收藏
页码:1368 / 1371
页数:4
相关论文
共 24 条
[1]
A simple structural-based approach to prevent aminoglycoside inactivation by bacterial defense proteins.: Conformational restriction provides effective protection against neomycin-B nucleotidylation by ANT4
[J].
Asensio, JL
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Asensio, JL
;
Hidalgo, A
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Hidalgo, A
;
Bastida, A
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Bastida, A
;
Torrado, M
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Torrado, M
;
Corzana, F
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Corzana, F
;
Chiara, JL
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Chiara, JL
;
García-Junceda, E
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
García-Junceda, E
;
Cañada, J
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Cañada, J
;
Jiménez-Barbero, J
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Jiménez-Barbero, J
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
2005,
127
(23)
:8278
-8279
[2]
Exploring the use of conformationally locked aminoglycosides as a new strategy to overcome bacterial resistance
[J].
Bastida, A
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Bastida, A
;
Hidalgo, A
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Hidalgo, A
;
Chiara, JL
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Chiara, JL
;
Torrado, M
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Torrado, M
;
Corzana, F
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Corzana, F
;
Pérez-Cañadillas, JM
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Pérez-Cañadillas, JM
;
Groves, P
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Groves, P
;
Garcia-Junceda, E
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Garcia-Junceda, E
;
Gonzalez, C
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Gonzalez, C
;
Jimenez-Barbero, J
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Jimenez-Barbero, J
;
Asensio, JL
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Asensio, JL
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
2006,
128
(01)
:100
-116
[3]
X-ray structure of the AAC(6′)-Ii antibiotic resistance enzyme at 1.8 Å resolution;: examination of oligomeric arrangements in GNAT superfamily members
[J].
Burk, DL
论文数:
0
引用数:
0
h-index:
0
机构:
McGill Univ, Dept Biochem, Montreal, PQ H3A 2B4, Canada
Burk, DL
;
Ghuman, N
论文数:
0
引用数:
0
h-index:
0
机构:
McGill Univ, Dept Biochem, Montreal, PQ H3A 2B4, Canada
Ghuman, N
;
Wybenga-Groot, LE
论文数:
0
引用数:
0
h-index:
0
机构:
McGill Univ, Dept Biochem, Montreal, PQ H3A 2B4, Canada
Wybenga-Groot, LE
;
Berghuis, AM
论文数:
0
引用数:
0
h-index:
0
机构:
McGill Univ, Dept Biochem, Montreal, PQ H3A 2B4, Canada
Berghuis, AM
.
PROTEIN SCIENCE,
2003,
12
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-437
[4]
Salmonella enterica serovar typhimurium blaPER-1-carrying plasmid pSTI1 encodes an extended-spectrum aminoglycoside 6'-N-acetyltransferase of type Ib
[J].
Casin, I
论文数:
0
引用数:
0
h-index:
0
机构:
Hop St Louis, Microbiol Serv, F-75010 Paris, France
Casin, I
;
Hanau-Berçot, B
论文数:
0
引用数:
0
h-index:
0
机构:
Hop St Louis, Microbiol Serv, F-75010 Paris, France
Hanau-Berçot, B
;
Podglajen, I
论文数:
0
引用数:
0
h-index:
0
机构:
Hop St Louis, Microbiol Serv, F-75010 Paris, France
Podglajen, I
;
论文数:
引用数:
h-index:
机构:
Vahaboglu, H
;
Collatz, E
论文数:
0
引用数:
0
h-index:
0
机构:
Hop St Louis, Microbiol Serv, F-75010 Paris, France
Collatz, E
.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,
2003,
47
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[5]
NOE pumping. 2. A high-throughput method to determine compounds with binding affinity to macromolecules by NMR
[J].
Chen, AD
论文数:
0
引用数:
0
h-index:
0
机构:
Novartis Inst Biomed Res, Summit, NJ 07901 USA
Novartis Inst Biomed Res, Summit, NJ 07901 USA
Chen, AD
;
Shapiro, MJ
论文数:
0
引用数:
0
h-index:
0
机构:
Novartis Inst Biomed Res, Summit, NJ 07901 USA
Novartis Inst Biomed Res, Summit, NJ 07901 USA
Shapiro, MJ
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
2000,
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Chung F., 2007, ANGEW CHEM, V119, P4573
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NMR-Guided fragment-based approach for the design of tRNALys3 ligands
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Chung, Florence
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Paris 05, CNRS, Cristallogr & RMN Biol, F-75006 Paris, France
Univ Paris 05, CNRS, Cristallogr & RMN Biol, F-75006 Paris, France
Chung, Florence
;
Tisne, Carine
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Paris 05, CNRS, Cristallogr & RMN Biol, F-75006 Paris, France
Univ Paris 05, CNRS, Cristallogr & RMN Biol, F-75006 Paris, France
Tisne, Carine
;
Lecourt, Thomas
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Paris 05, CNRS, Cristallogr & RMN Biol, F-75006 Paris, France
Univ Paris 05, CNRS, Cristallogr & RMN Biol, F-75006 Paris, France
Lecourt, Thomas
;
Dardel, Frederic
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Paris 05, CNRS, Cristallogr & RMN Biol, F-75006 Paris, France
Univ Paris 05, CNRS, Cristallogr & RMN Biol, F-75006 Paris, France
Dardel, Frederic
;
论文数:
引用数:
h-index:
机构:
Micouin, Laurent
.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,
2007,
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Molecular recognition of aminoglycoside antibiotics by bacterial defence proteins:: NMR study of the structural and conformational features of streptomycin inactivation by Bacillus subtilis aminoglycoside-6-adenyl transferase
[J].
Corzana, F
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Corzana, F
;
Cuesta, I
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Cuesta, I
;
Bastida, A
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Bastida, A
;
Hidalgo, A
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Hidalgo, A
;
Latorre, M
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Latorre, M
;
González, C
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
González, C
;
García-Junceda, E
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
García-Junceda, E
;
Jiménez-Barbero, J
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Jiménez-Barbero, J
;
Asensio, JL
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Asensio, JL
.
CHEMISTRY-A EUROPEAN JOURNAL,
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Molecular mechanism of the enterococcal aminoglycoside 6′-N-acetyltransferase′:: Role of GNAT-conserved residues in the chemistry of antibiotic inactivation
[J].
Draker, KA
论文数:
0
引用数:
0
h-index:
0
机构:
McMaster Univ, Dept Biochem, Antimicrobial Res Ctr, Hamilton, ON L8N 3Z5, Canada
McMaster Univ, Dept Biochem, Antimicrobial Res Ctr, Hamilton, ON L8N 3Z5, Canada
Draker, KA
;
Wright, GD
论文数:
0
引用数:
0
h-index:
0
机构:
McMaster Univ, Dept Biochem, Antimicrobial Res Ctr, Hamilton, ON L8N 3Z5, Canada
McMaster Univ, Dept Biochem, Antimicrobial Res Ctr, Hamilton, ON L8N 3Z5, Canada
Wright, GD
.
BIOCHEMISTRY,
2004,
43
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Kinetic mechanism of the GCN5-related chromosomal aminoglycoside acetyltransferase AAC(6′)-Ii from Enterococcus faecium:: Evidence of dimer subunit cooperativity
[J].
Draker, KA
论文数:
0
引用数:
0
h-index:
0
机构:
McMaster Univ, Dept Biochem, Antimicrobial Res Ctr, Hamilton, ON L8N 3Z5, Canada
Draker, KA
;
Northrop, DB
论文数:
0
引用数:
0
h-index:
0
机构:
McMaster Univ, Dept Biochem, Antimicrobial Res Ctr, Hamilton, ON L8N 3Z5, Canada
Northrop, DB
;
Wright, GD
论文数:
0
引用数:
0
h-index:
0
机构:
McMaster Univ, Dept Biochem, Antimicrobial Res Ctr, Hamilton, ON L8N 3Z5, Canada
Wright, GD
.
BIOCHEMISTRY,
2003,
42
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←
1
2
3
→
共 24 条
[1]
A simple structural-based approach to prevent aminoglycoside inactivation by bacterial defense proteins.: Conformational restriction provides effective protection against neomycin-B nucleotidylation by ANT4
[J].
Asensio, JL
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Asensio, JL
;
Hidalgo, A
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Hidalgo, A
;
Bastida, A
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Bastida, A
;
Torrado, M
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Torrado, M
;
Corzana, F
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Corzana, F
;
Chiara, JL
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Chiara, JL
;
García-Junceda, E
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
García-Junceda, E
;
Cañada, J
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Cañada, J
;
Jiménez-Barbero, J
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain
Jiménez-Barbero, J
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
2005,
127
(23)
:8278
-8279
[2]
Exploring the use of conformationally locked aminoglycosides as a new strategy to overcome bacterial resistance
[J].
Bastida, A
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Bastida, A
;
Hidalgo, A
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Hidalgo, A
;
Chiara, JL
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Chiara, JL
;
Torrado, M
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Torrado, M
;
Corzana, F
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Corzana, F
;
Pérez-Cañadillas, JM
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Pérez-Cañadillas, JM
;
Groves, P
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Groves, P
;
Garcia-Junceda, E
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Garcia-Junceda, E
;
Gonzalez, C
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Gonzalez, C
;
Jimenez-Barbero, J
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Jimenez-Barbero, J
;
Asensio, JL
论文数:
0
引用数:
0
h-index:
0
机构:
CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
Asensio, JL
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
2006,
128
(01)
:100
-116
[3]
X-ray structure of the AAC(6′)-Ii antibiotic resistance enzyme at 1.8 Å resolution;: examination of oligomeric arrangements in GNAT superfamily members
[J].
Burk, DL
论文数:
0
引用数:
0
h-index:
0
机构:
McGill Univ, Dept Biochem, Montreal, PQ H3A 2B4, Canada
Burk, DL
;
Ghuman, N
论文数:
0
引用数:
0
h-index:
0
机构:
McGill Univ, Dept Biochem, Montreal, PQ H3A 2B4, Canada
Ghuman, N
;
Wybenga-Groot, LE
论文数:
0
引用数:
0
h-index:
0
机构:
McGill Univ, Dept Biochem, Montreal, PQ H3A 2B4, Canada
Wybenga-Groot, LE
;
Berghuis, AM
论文数:
0
引用数:
0
h-index:
0
机构:
McGill Univ, Dept Biochem, Montreal, PQ H3A 2B4, Canada
Berghuis, AM
.
PROTEIN SCIENCE,
2003,
12
(03)
:426
-437
[4]
Salmonella enterica serovar typhimurium blaPER-1-carrying plasmid pSTI1 encodes an extended-spectrum aminoglycoside 6'-N-acetyltransferase of type Ib
[J].
Casin, I
论文数:
0
引用数:
0
h-index:
0
机构:
Hop St Louis, Microbiol Serv, F-75010 Paris, France
Casin, I
;
Hanau-Berçot, B
论文数:
0
引用数:
0
h-index:
0
机构:
Hop St Louis, Microbiol Serv, F-75010 Paris, France
Hanau-Berçot, B
;
Podglajen, I
论文数:
0
引用数:
0
h-index:
0
机构:
Hop St Louis, Microbiol Serv, F-75010 Paris, France
Podglajen, I
;
论文数:
引用数:
h-index:
机构:
Vahaboglu, H
;
Collatz, E
论文数:
0
引用数:
0
h-index:
0
机构:
Hop St Louis, Microbiol Serv, F-75010 Paris, France
Collatz, E
.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,
2003,
47
(02)
:697
-703
[5]
NOE pumping. 2. A high-throughput method to determine compounds with binding affinity to macromolecules by NMR
[J].
Chen, AD
论文数:
0
引用数:
0
h-index:
0
机构:
Novartis Inst Biomed Res, Summit, NJ 07901 USA
Novartis Inst Biomed Res, Summit, NJ 07901 USA
Chen, AD
;
Shapiro, MJ
论文数:
0
引用数:
0
h-index:
0
机构:
Novartis Inst Biomed Res, Summit, NJ 07901 USA
Novartis Inst Biomed Res, Summit, NJ 07901 USA
Shapiro, MJ
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
2000,
122
(02)
:414
-415
[6]
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