Innate immune stimulation of exo-polymers prepared from Cordyceps sinensis by submerged culture

被引：29

作者：

Yoon, Taek Joon ^{[2
]}

Yu, Kwang-Won ^{[3
]}

Shin, Kwang-Soon ^{[4
]}

Suh, Hyung Joo ^{[1
]}

机构：

[1] Korea Univ, Dept Food & Nutr, Seoul 136703, South Korea

[2] Yuhan Coll, Dept Food & Nutr, Puchon 422749, South Korea

[3] Chungju Natl Univ, Div Food & Biotechnol, Chungju 368701, Chungbuk, South Korea

[4] Kyonggi Univ, Dept Food Sci & Biotechnol, Suwon 443760, Kyonggi Do, South Korea

来源：

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2008年 / 80卷 / 06期

关键词：

Cordyceps sinensis; innate immunity; exo-polymer; cytokine; NK cell; tumor metastasis;

D O I：

10.1007/s00253-008-1607-y

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

After we prepared exo-polymers (EPS) from Cordyceps sinensis by submerged culture, prophylactic intravenous administration (i.v.) of EPS significantly inhibited metastasis in experimental lung metastasis of colon 26-M3.1 carcinoma. Cytotoxicity against Yac-1 tumor cells of natural killer (NK) cell, which was prepared by i.v. of EPS (100 mu g/mouse), significantly augmented 2 days after EPS treatment. When NK cells were depleted by rabbit anti-asialo GM1 serum, even the EPS group totally abolished the inhibitory effect on lung metastasis of colon 26-M3.1 cells. EPS can stimulate innate immune system to inhibit tumor metastasis, and its anti-tumor metastasis is associated with macrophage and NK cell activation.

引用

页码：1087 / 1093

页数：7

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