Roles of microRNAs beyond development - Metabolism and neural plasticity

被引：36

作者：

Aumiller, Verena ^{[1
]}

Foerstemann, Klaus ^{[1
,2
]}

机构：

[1] Univ Munich, Dept Chem & Biochem, Gene Ctr, Munich, Germany

[2] Univ Munich, Munich Ctr Integrated Prot Sci CiPSM, Munich, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2008年 / 1779卷 / 11期

关键词：

miRNA; microRNA; mode of miRNA-action; metabolism; neural plasticity;

D O I：

10.1016/j.bbagrm.2008.04.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The importance of microRNAs during development is well recognized, but a number of studies indicate that their function extends to differentiated cells as well. Metabolic control and neural plasticity are dynamic processes in adult organisms and represent good examples where miRNA-mediated regulation affects the function of differentiated cells without changing their fate. We are summarizing the current understanding of how microRNAs contribute to post-transcriptional control of gene expression in these processes and, where possible, highlight in which mode of action - the "guardian" or the "tuning mode" - they are employed by the cell. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：692 / 696

页数：5