The ErbB receptor family: a therapeutic target for cancer

被引：162

作者：

de Bono, JS

Rowinsky, EK

机构：

[1] Univ Texas, Hlth Sci Ctr, Canc Therapy & Res Fdn, Inst Drug Dev, San Antonio, TX 78229 USA

[2] Univ Texas, Hlth Sci Ctr, Div Med Oncol, San Antonio, TX 78229 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2002年 / 8卷 / 04期

关键词：

D O I：

10.1016/S1471-4914(02)02306-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This article reviews the current state of efforts targeting the ErbB family of tyrosine kinase receptors in cancer therapy. In particular, preliminary results will be discussed of studies of the first generation of therapeutics to enter clinical evaluation in malignant diseases. Results of recently conducted clinical studies with ZD1839 (Iressa(R)), OSI-774 (Tarceva(R)), Cetuximab(R) (IMC-C225) and trastuzumab (Herceptin(R)) and several other compounds are presented. Potential advantages and disadvantages of these different therapeutic modalities, as well as future challenges of evaluating ErbB-targeted agents in the clinic, are presented.

引用

页码：S19 / S26

页数：8

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