Role of macrophage migration inhibitory factor in hepatitis B virus-specific cytotoxic-T-lymphocyte-induced liver injury

被引：20

作者：

Kimura, K

Nagaki, M

Nishihira, J

Satake, S

Kuwata, K

Moriwaki, H

机构：

[1] Gifu Univ, Ctr Dept Emerging Infect Dis, Gifu 5011194, Japan

[2] Gifu Univ, Sch Med, Dept Internal Med 1, Gifu 5011194, Japan

[3] GeneticLab, Dept Res & Dev, Sapporo, Hokkaido 0608638, Japan

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2006年 / 13卷 / 03期

关键词：

D O I：

10.1128/CVI.13.3.415-419.2006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Macrophage migration inhibitory factor (MIF) plays a pivotal role in the development of various inflammatory diseases. Here, we found that anti-mouse MIF antibody treatment reduced liver injury and inflammatory cell infiltration into the liver after injection of antigen-specific cytotoxic T lymphocytes into hepatitis B virus transgenic mice.

引用

收藏

页码：415 / 419

页数：5

相关论文

共 24 条

[1]

MECHANISMS OF CLASS-I RESTRICTED IMMUNOPATHOLOGY - A TRANSGENIC MOUSE MODEL OF FULMINANT-HEPATITIS [J].

ANDO, K ;

MORIYAMA, T ;

GUIDOTTI, LG ;

WIRTH, S ;

SCHREIBER, RD ;

SCHLICHT, HJ ;

HUANG, SN ;

CHISARI, FV .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (05) :1541-1554

[2]

Bacher M, 1997, AM J PATHOL, V150, P235

[3]

Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis [J].

Bozza, M ;

Satoskar, AR ;

Lin, GS ;

Lu, B ;

Humbles, AA ;

Gerard, C ;

David, JR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (02) :341-346

[4]

MACROPHAGE IS AN IMPORTANT AND PREVIOUSLY UNRECOGNIZED SOURCE OF MACROPHAGE-MIGRATION INHIBITORY FACTOR [J].

CALANDRA, T ;

BERNHAGEN, J ;

MITCHELL, RA ;

BUCALA, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (06) :1895-1902

[5]

Macrophage migration inhibitory factor: A regulator of innate immunity [J].

Calandra, T ;

Roger, T .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (10) :791-800

[6]

Protection from septic shock by neutralization of macrophage migration inhibitory factor [J].

Calandra, T ;

Echtenacher, B ;

Le Roy, D ;

Pugin, J ;

Metz, CN ;

Hültner, L ;

Heumann, D ;

Männel, D ;

Bucala, R ;

Glauser, MP .

NATURE MEDICINE, 2000, 6 (02) :164-170

[7]

Interleukin-12 inhibits hepatitis B virus replication in transgenic mice [J].

Cavanaugh, VJ ;

Guidotti, LG ;

Chisari, FV .

JOURNAL OF VIROLOGY, 1997, 71 (04) :3236-3243

[8]

DELAYED HYPERSENSITIVITY IN VITRO - ITS MEDIATION BY CELL-FREE SUBSTANCES FORMED BY LYMPHOID CELL-ANTIGEN INTERACTION [J].

DAVID, JR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1966, 56 (01) :72-&

[9]

Development of chronic colitis is dependent on the cytokine MIF [J].

de Jong, YP ;

Abadia-Molina, AC ;

Satoskar, AR ;

Clarke, K ;

Rietdijk, ST ;

Faubion, WA ;

Mizoguchi, E ;

Metz, CN ;

Al Sahli, M ;

ten Hove, T ;

Keates, AC ;

Lubetsky, JB ;

Farrell, RJ ;

Michetti, P ;

van Deventer, SJ ;

Lolis, E ;

David, JR ;

Bhan, AK ;

Terhorst, C .

NATURE IMMUNOLOGY, 2001, 2 (11) :1061-1066

[10]

Franco A, 1997, J IMMUNOL, V159, P2001