Prednisolone (30-60 mg/day) for diseases other than AD decreases amyloid β-peptides in CSF

被引：12

作者：

Tokuda, T

Oide, T

Tamaoka, A

Ishii, K

Matsuno, S

Ikeda, S

机构：

[1] Shinshu Univ, Sch Med, Dept Internal Med 3, Matsumoto, Nagano 3908621, Japan

[2] Univ Tsukuba, Inst Clin Med, Dept Neurol, Tsukuba, Ibaraki, Japan

来源：

NEUROLOGY | 2002年 / 58卷 / 09期

关键词：

D O I：

10.1212/WNL.58.9.1415

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effect of corticosteroid on the concentration of amyloid beta-peptide (Abeta) in human CSF obtained from 16 patients without dementia treated with prednisolone (greater than or equal to30 mg daily) was studied. The concentrations of Abetax-40 and Abetax-42 in CSF decreased after treatment was started (p < 0.002). A moderate- or high-dose regimen of prednisolone decreases Abeta production or increases Abeta degradation in the human brain and deserves further study in AD.

引用

页码：1415 / 1418

页数：4

共 11 条

[1] A randomized controlled trial of prednisone in Alzheimer's disease [J].

Aisen, PS ;

Davis, KL ;

Berg, JD ;

Schafer, K ;

Campbell, K ;

Thomas, RG ;

Weiner, MF ;

Farlow, MR ;

Sano, M ;

Grundman, M ;

Thal, LJ .

NEUROLOGY, 2000, 54 (03) :588-593

[2] Inflammation and Alzheimer's disease [J].

Akiyama, H ;

Barger, S ;

Barnum, S ;

Bradt, B ;

Bauer, J ;

Cole, GM ;

Cooper, NR ;

Eikelenboom, P ;

Emmerling, M ;

Fiebich, BL ;

Finch, CE ;

Frautschy, S ;

Griffin, WST ;

Hampel, H ;

Hull, M ;

Landreth, G ;

Lue, LF ;

Mrak, R ;

Mackenzie, IR ;

McGeer, PL ;

O'Banion, MK ;

Pachter, J ;

Pasinetti, G ;

Plata-Salaman, C ;

Rogers, J ;

Rydel, R ;

Shen, Y ;

Streit, W ;

Strohmeyer, R ;

Tooyoma, I ;

Van Muiswinkel, FL ;

Veerhuis, R ;

Walker, D ;

Webster, S ;

Wegrzyniak, B ;

Wenk, G ;

Wyss-Coray, T .

NEUROBIOLOGY OF AGING, 2000, 21 (03) :383-421

[3] Cessation of cerebral hemorrhage recurrence associated with corticosteroid treatment in a patient with cerebral amyloid angiopathy [J].

Hoshi, K ;

Yoshida, K ;

Nakamura, A ;

Tada, T ;

Tamaoka, A ;

Ikeda, S .

AMYLOID-INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION, 2000, 7 (04) :284-288

[4] Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease [J].

Lim, GP ;

Yang, F ;

Chu, T ;

Chen, P ;

Beech, W ;

Teter, B ;

Tran, T ;

Ubeda, O ;

Ashe, KH ;

Frautschy, SA ;

Cole, GM .

JOURNAL OF NEUROSCIENCE, 2000, 20 (15) :5709-5714

[5] Mini-review - The importance of inflammatory mechanisms in Alzheimer disease [J].

McGeer, EG ;

McGeer, PL .

EXPERIMENTAL GERONTOLOGY, 1998, 33 (05) :371-378

[6] Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies [J].

McGeer, PL ;

Schulzer, M ;

McGeer, EG .

NEUROLOGY, 1996, 47 (02) :425-432

[7] NEUROFIBRILLARY TANGLES AND SENILE PLAQUES IN BRAIN OF ELDERLY LEPROSY PATIENTS [J].

NAMBA, Y ;

KAWATSU, K ;

IZUMI, S ;

UEKI, A ;

IKEDA, K .

LANCET, 1992, 340 (8825) :978-978

[8]

Tamaoka A, 1999, ANN NEUROL, V46, P933, DOI 10.1002/1531-8249(199912)46:6<933::AID-ANA20>3.0.CO

[9]

2-4

[10] Amyloid beta protein 42(43) in cerebrospinal fluid of patients with Alzheimer's disease [J].

Tamaoka, A ;

Sawamura, N ;

Fukushima, T ;

Shoji, S ;

Matsubara, E ;

Shoji, M ;

Hirai, S ;

Furiya, Y ;

Endoh, R ;

Mori, H .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1997, 148 (01) :41-45

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