Genetic aberrations of signaling pathways in lymphomagenesis: Revelations from next generation sequencing studies

被引：58

作者：

Rossi, Davide ^{[1
]}

Ciardullo, Carmela ^{[1
]}

Gaidano, Gianluca ^{[1
]}

机构：

[1] Amedeo Avogadro Univ Eastern Piedmont, Dept Translat Med, Div Hematol, I-28100 Novara, Italy

来源：

SEMINARS IN CANCER BIOLOGY | 2013年 / 23卷 / 06期

关键词：

Next generation sequencing; Lymphoma; Chronic lymphocytic leukemia; Hairy cell leukemia; Mutation; CHRONIC LYMPHOCYTIC-LEUKEMIA; HAIRY-CELL LEUKEMIA; NF-KAPPA-B; IDENTIFIES RECURRENT MUTATIONS; MARGINAL ZONE LYMPHOMA; NOTCH1; MUTATIONS; CODING GENOME; SOMATIC MUTATIONS; TUMOR-SUPPRESSOR; SF3B1;

D O I：

10.1016/j.semcancer.2013.04.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Next generation sequencing (NGS) technology has led to a burst of disease-relevant molecular information in a variety of lymphoid tumors, including chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, Burkitt lymphoma, Waldenstrom macroglobulinemia, hairy cell leukemia, and splenic marginal zone lymphoma. Beside disclosing comprehensive catalogs of somatic mutations and new insights into the genes that contribute to cellular transformation, NGS has also provided molecular clues useful for addressing a number of unmet clinical needs in the field of B-cell tumor management, including biomarkers for disease diagnosis and classification improvement (i.e. mutations of BRAF, MYD88 and NOTCH2), and new targets to be translated into therapeutic interventions (i.e. BCR, TLR, NOTCH, NF-kappa B and MAPK signaling pathways). This review summarizes the molecular lesions of signaling pathways that have been discovered in B-cell lymphoproliferative disorders by NGS studies. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：422 / 430

页数：9

共 70 条

[1]

The BRAF V600E mutation in hairy cell leukemia and other mature B-cell neoplasms [J].

Arcaini, Luca ;

Zibellini, Silvia ;

Boveri, Emanuela ;

Riboni, Roberta ;

Rattotti, Sara ;

Varettoni, Marzia ;

Guerrera, Maria Luisa ;

Lucioni, Marco ;

Tenore, Annamaria ;

Merli, Michele ;

Rizzi, Silvia ;

Morello, Lucia ;

Cavalloni, Chiara ;

Da Via, Matteo C. ;

Paulli, Marco ;

Cazzola, Mario .

BLOOD, 2012, 119 (01) :188-191

[2]

Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies [J].

Aster, Jon C. ;

Blacklow, Stephen C. ;

Pear, Warren S. .

JOURNAL OF PATHOLOGY, 2011, 223 (02) :262-273

[3]

NOTCH1 mutations in CLL associated with trisomy 12 [J].

Balatti, Veronica ;

Bottoni, Arianna ;

Palamarchuk, Alexey ;

Alder, Hansjuerg ;

Rassenti, Laura Z. ;

Kipps, Thomas J. ;

Pekarsky, Yuri ;

Croce, Carlo M. .

BLOOD, 2012, 119 (02) :329-331

[4]

Combined Genetic Inactivation of β2-Microglobulin and CD58 Reveals Frequent Escape from Immune Recognition in Diffuse Large B Cell Lymphoma [J].

Challa-Malladi, Madhavi ;

Lieu, Yen K. ;

Califano, Olivia ;

Holmes, Antony B. ;

Bhagat, Govind ;

Murty, Vundavalli V. ;

Dominguez-Sola, David ;

Pasqualucci, Laura ;

Dalla-Favera, Riccardo .

CANCER CELL, 2011, 20 (06) :728-740

[5]

Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma [J].

Compagno, Mara ;

Lim, Wei Keat ;

Grunn, Adina ;

Nandula, Subhadra V. ;

Brahmachary, Manisha ;

Shen, Qiong ;

Bertoni, Francesco ;

Ponzoni, Maurilio ;

Scandurra, Marta ;

Califano, Andrea ;

Bhagat, Govind ;

Chadburn, Amy ;

Dalla-Favera, Riccardo ;

Pasqualucci, Laura .

NATURE, 2009, 459 (7247) :717-U124

[6]

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma [J].

Davis, R. Eric ;

Ngo, Vu N. ;

Lenz, Georg ;

Tolar, Pavel ;

Young, Ryan M. ;

Romesser, Paul B. ;

Kohlhammer, Holger ;

Lamy, Laurence ;

Zhao, Hong ;

Yang, Yandan ;

Xu, Weihong ;

Shaffer, Arthur L. ;

Wright, George ;

Xiao, Wenming ;

Powell, John ;

Jiang, Jian-Kang ;

Thomas, Craig J. ;

Rosenwald, Andreas ;

Ott, German ;

Muller-Hermelink, Hans Konrad ;

Gascoyne, Randy D. ;

Connors, Joseph M. ;

Johnson, Nathalie A. ;

Rimsza, Lisa M. ;

Campo, Elias ;

Jaffe, Elaine S. ;

Wilson, Wyndham H. ;

Delabie, Jan ;

Smeland, Erlend B. ;

Fisher, Richard I. ;

Braziel, Rita M. ;

Tubbs, Raymond R. ;

Cook, J. R. ;

Weisenburger, Dennis D. ;

Chan, Wing C. ;

Pierce, Susan K. ;

Staudt, Louis M. .

NATURE, 2010, 463 (7277) :88-U97

[7]

NOTCH1 mutations in+12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of+12 CLL [J].

Del Giudice, Ilaria ;

Rossi, Davide ;

Chiaretti, Sabina ;

Marinelli, Marilisa ;

Tavolaro, Simona ;

Gabrielli, Sara ;

Laurenti, Luca ;

Marasca, Roberto ;

Rasi, Silvia ;

Fangazio, Marco ;

Guarini, Anna ;

Gaidano, Gianluca ;

Foa, Robin .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2012, 97 (03) :437-441

[8]

Dietrich S, 2012, NEW ENGL J MED, V366, P2038, DOI 10.1056/NEJMc1202124

[9]

Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation [J].

Fabbri, Giulia ;

Rasi, Silvia ;

Rossi, Davide ;

Trifonov, Vladimir ;

Khiabanian, Hossein ;

Ma, Jing ;

Grunn, Adina ;

Fangazio, Marco ;

Capello, Daniela ;

Monti, Sara ;

Cresta, Stefania ;

Gargiulo, Ernesto ;

Forconi, Francesco ;

Guarini, Anna ;

Arcaini, Luca ;

Paulli, Marco ;

Laurenti, Luca ;

Larocca, Luigi M. ;

Marasca, Roberto ;

Gattei, Valter ;

Oscier, David ;

Bertoni, Francesco ;

Mullighan, Charles G. ;

Foa, Robin ;

Pasqualucci, Laura ;

Rabadan, Raul ;

Dalla-Favera, Riccardo ;

Gaidano, Gianluca .

JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (07) :1389-1401

[10]

Rapid response of biallelic BRAF V600E mutated hairy cell leukaemia to low dose vemurafenib [J].

Follows, George A. ;

Sims, Hannah ;

Bloxham, David M. ;

Zenz, Thorsten ;

Hopper, Melanie A. ;

Liu, Hongxiang ;

Bench, Anthony ;

Wright, Penny ;

van't Veer, Mars B. ;

Scott, Mike A. .

BRITISH JOURNAL OF HAEMATOLOGY, 2013, 161 (01) :150-153

← 1 2 3 4 5 6 7 →