Arctigenin protects against liver injury from acute hepatitis by suppressing immune cells in mice

被引：14

作者：

Cheng, Xixi ^{[1
,3
]}

Wang, Huafeng ^{[2
]}

Yang, Jinlai ^{[1
]}

Cheng, Yingnan ^{[1
]}

Wang, Dan ^{[1
]}

Yang, Fengrui ^{[1
]}

Li, Yan ^{[1
]}

Zhou, Dongmei ^{[1
]}

Wang, Yanxia ^{[2
]}

Xue, Zhenyi ^{[1
]}

Zhang, Lijuan ^{[1
]}

Zhang, Qi ^{[1
]}

Yang, Luhong ^{[2
]}

Zhang, Rongxin ^{[1
,4
]}

Da, Yurong ^{[1
]}

机构：

[1] Tianjin Med Univ, Tianjin Key Lab Cellular & Mol Immunol, Key Lab Immune Microenvironm & Dis, Educ Minist China,Dept Immunol, Qi Xiang Tai Rd 22, Tianjin 300070, Peoples R China

[2] Shanxi Normal Univ, Sch Life Sci, Linfen, Peoples R China

[3] Binhai New Area Hosp Tradit Chinese Med, Dept Clin Lab, Tianjin, Peoples R China

[4] Guangdong Pharmaceut Univ, Sch Biosci & Biopharmaceut, Lab Immunol & Inflammat, Guangzhou, Guangdong, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2018年 / 102卷

基金：

中国国家自然科学基金;

关键词：

Arctigenin; Immunological hepatitis; Macrophage; Inflammation; AUTOIMMUNE ENCEPHALOMYELITIS; MACROPHAGES; PROGRESSION; EXPRESSION;

D O I：

10.1016/j.biopha.2018.03.060

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

As a phenylpropanoid and dibenzylbutyrolactone lignan present in medical plants, such as those used in traditional Chinese herbal medicine, including Arctium lappa (Niubang), arctigenin exhibits antimicrobial, antiinflammatory, and anticancer activities. In this study, we investigated the protective role of arctigenin in Concanavalin A (ConA)-induced acute hepatitis in mice. Arctigenin remarkably reduced the congestion and necroinflammation of livers, and improved hepatic function (ALT and AST) in ConA-induced acute hepatitis in vivo. The infiltration of CD4 T, NKT and macrophages into the livers was found to be reduced with arctigenin treatment. Arctigenin suppressed ConA-induced T lymphocyte proliferations that might have resulted from enhanced IL-10 production by macrophages and CD4 T cells. These results suggested that arctigenin could be a powerful drug candidate for acute hepatitis through immune suppression.

引用

页码：464 / 471

页数：8

共 25 条

[1]

Vorinostat, a histone deacetylase inhibitor, suppresses dendritic cell function and ameliorates experimental autoimmune encephalomyelitis [J].