New classification of oesophageal and gastric carcinomas derived from changing patterns in epidemiology

被引:109
作者
Dolan, K
Sutton, R
Walker, SJ
Morris, AI
Campbell, F
Williams, EMI
机构
[1] Royal Liverpool Univ Hosp, Dept Surg, Liverpool L69 36A, Merseyside, England
[2] Royal Liverpool Univ Hosp, Dept Gastroenterol, Liverpool L69 36A, Merseyside, England
[3] Royal Liverpool Univ Hosp, Dept Pathol, Liverpool L69 36A, Merseyside, England
[4] Univ Liverpool, Dept Publ Hlth, Liverpool L69 3BX, Merseyside, England
关键词
oesophageal carcinoma; gastric carcinoma; epidemiology; classification;
D O I
10.1038/sj.bjc.6690429
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The current ICD-O classification of carcinomas of the oesophagus and stomach causes epidemiological and clinical confusion. This study compares the epidemiological and clinical features of each subtype and subsite of adenocarcinomas of the oesophagus and stomach, to assess requirements for a new classification of these carcinomas, Data were extracted with appropriate validity checks on all cases of oesophageal and gastric carcinomas identified throughout the period 1974-1993 by the Merseyside and Cheshire Cancer Registry, which covers a population of 2.5 million. The incidence of adenocarcinomas of the lower oesophagus and cardia trebled in males, and doubled in females, whereas adenocarcinoma of the subcardia region of the stomach declined in both sexes. Adenocarcinomas of the lower oesophagus and of the cardia were similar for median age at diagnosis, male to female ratio, percentage of patients who smoked and survival; both were significantly different from carcinomas of the subcardia in these respects. These data imply that adenocarcinomas of the lower oesophagus and cardia are the same disease. A new subsite classification of oesophageal and gastric carcinomas is proposed that includes the gastro-oesophageal junction as a distinct subsite, to facilitate surveillance, management and research.
引用
收藏
页码:834 / 842
页数:9
相关论文
共 36 条
[1]  
ANTONIOLI DA, 1982, CANCER, V50, P775, DOI 10.1002/1097-0142(19820815)50:4<775::AID-CNCR2820500425>3.0.CO
[2]  
2-W
[3]   RISING INCIDENCE OF ADENOCARCINOMA OF THE ESOPHAGUS AND GASTRIC CARDIA [J].
BLOT, WJ ;
DEVESA, SS ;
KNELLER, RW ;
FRAUMENI, JF .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1991, 265 (10) :1287-1289
[4]   AMBULATORY ESOPHAGEAL BILE REFLUX MONITORING IN BARRETTS-ESOPHAGUS [J].
CALDWELL, MTP ;
LAWLOR, P ;
BYRNE, PJ ;
WALSH, TN ;
HENNESSY, TPJ .
BRITISH JOURNAL OF SURGERY, 1995, 82 (05) :657-660
[5]   ADENOCARCINOMA OF THE ESOPHAGOGASTRIC JUNCTION AND BARRETTS-ESOPHAGUS [J].
CAMERON, AJ ;
LOMBOY, CT ;
PERA, M ;
CARPENTER, HA .
GASTROENTEROLOGY, 1995, 109 (05) :1541-1546
[6]   THE RELATION OF GASTROESOPHAGEAL REFLUX DISEASE AND ITS TREATMENT TO ADENOCARCINOMAS OF THE ESOPHAGUS AND GASTRIC CARDIA [J].
CHOW, WH ;
FINKLE, WD ;
MCLAUGHLIN, JK ;
FRANKL, H ;
ZIEL, HK ;
FRAUMENI, JF .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 274 (06) :474-477
[7]  
CORREA P, 1994, CANCER SURV, V20, P55
[8]  
CRAANEN ME, 1992, AM J GASTROENTEROL, V87, P572
[9]   LOCATION OF THE LOWER ESOPHAGEAL SPHINCTER AND THE SQUAMOUS COLUMNAR MUCOSAL JUNCTION IN 109 HEALTHY CONTROLS AND 778 PATIENTS WITH DIFFERENT DEGREES OF ENDOSCOPIC ESOPHAGITIS [J].
CSENDES, A ;
MALUENDA, F ;
BRAGHETTO, I ;
CSENDES, P ;
HENRIQUEZ, A ;
QUESADA, MS .
GUT, 1993, 34 (01) :21-27
[10]  
Hansen S, 1997, INT J CANCER, V71, P340, DOI 10.1002/(SICI)1097-0215(19970502)71:3<340::AID-IJC5>3.0.CO