First trimester screening for Down's syndrome after assisted reproductive technology: non-male factor infertility is associated with elevated free beta-human chorionic gonadotropin levels at 10-14 weeks of gestation

被引：27

作者：

Anckaert, Ellen ^{[1
]}

Schiettecatte, Johan ^{[1
]}

Sleurs, Elke ^{[2
]}

Devroey, Paul ^{[3
]}

Smitz, Johan ^{[1
]}

机构：

[1] Univ Ziekenhuis Brussel, Lab Hormonol & Tumour Markers, B-1090 Brussels, Belgium

[2] Univ Ziekenhuis Brussel, Dept Maternal Fetal Med, B-1090 Brussels, Belgium

[3] Univ Ziekenhuis Brussel, Ctr Reprod Med, B-1090 Brussels, Belgium

来源：

FERTILITY AND STERILITY | 2008年 / 90卷 / 04期

关键词：

D O I：

10.1016/j.fertnstert.2007.08.050

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We retrospectively compared the first trimester Down's syndrome serum screening markers free beta-hCG (f beta hCG) and pregnancy-associated plasma protein-A (PAPP-A) at 11-14 weeks of gestation in 4,088 women with naturally conceived pregnancies and in women pregnant after ICSI (n = 163), IVF (n = 59) and frozen-thawed embryo transfer (n = 31), and we searched for a potential relationship between infertility cause and marker levels. We found lower serum PAPP-A levels in pregnancies after IVF and ICSI compared with spontaneously conceived pregnancies and non-male factor infertility was associated with elevated serum f beta hCG levels at 11-14 weeks of gestation.

引用

页码：1206 / 1210

页数：5

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