Identified Cellular Correlates of Neocortical Ripple and High-Gamma Oscillations during Spindles of Natural Sleep

被引：45

作者：

Averkin, Robert G. ^{[1
]}

Szemenyei, Viktor ^{[1
]}

Borde, Sandor ^{[1
]}

Tamas, Gabor ^{[1
]}

机构：

[1] Univ Szeged, Dept Physiol Anat & Neurosci, MTA SZTE Res Grp Cort Microcircuits, Kozep Fasor 52, Szeged, Hungary

来源：

NEURON | 2016年 / 92卷 / 04期

关键词：

LOCAL-FIELD POTENTIALS; FAST-SPIKING CELLS; NEURONAL-ACTIVITY; INHIBITORY INTERNEURONS; SOMATOSENSORY CORTEX; MINIATURE MICRODRIVE; PREFRONTAL CORTEX; CORTICAL NETWORKS; IN-VIVO; HIPPOCAMPUS;

D O I：

10.1016/j.neuron.2016.09.032

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Ultra-high-frequency network events in the hippocampus are instrumental in a dialogue with the neocortex during memory formation, but the existence of transient similar to 200 Hz network events in the neocortex is not clear. Our recordings from neocortical layer II/III of freely behaving rats revealed field potential events at ripple and high-gamma frequencies repeatedly occurring at troughs of spindle oscillations during sleep. Juxtacellular recordings identified subpopulations of fast-spiking, parvalbumin-containing basket cells with epochs of firing at ripple (similar to 200 Hz) and high-gamma (similar to 120 Hz) frequencies detected during spindles and centered with millisecond precision at the trough of spindle waves in phase with field potential events but phase shifted relative to pyramidal cell firing. The results suggest that basket cell subpopulations are involved in spindle-nested, high-frequency network events that hypothetically provide repeatedly occurring neocortical temporal reference states potentially involved in mnemonic processes.

引用

页码：916 / 928

页数：13

共 59 条

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