Investigations into self-association of vancomycin covalent dimers using surface plasmon resonance technology

被引：21

作者：

Adamczyk, M ^{[1
]}

Moore, JA ^{[1
]}

Rege, SD ^{[1
]}

Yu, ZG ^{[1
]}

机构：

[1] Abbott Labs, Dept Chem, Div Diagnost, Dept 09NM, Abbott Pk, IL 60064 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(99)00402-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Covalent dimers of vancomycin linked through the vancosamine sugar moieties of the glycopeptide antibiotic have been synthesized in one step in 67-69% yield. The propensity for self-association of these and related vancomycin covalent dimers is evaluated using surface plasmon resonance technology. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2437 / 2440

页数：4

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