CAD/CAM and rapid prototyped scaffold construction for bone regenerative medicine and surgical transfer of virtual planning: A pilot study

被引：91

作者：

Ciocca, L. ^{[1
]}

De Crescenzio, F. ^{[2
]}

Fantini, M. ^{[2
]}

Scotti, R. ^{[3
]}

机构：

[1] Alma Mater Studiorum Univ Bologna, Dept Oral Sci, Sect Prosthodont, Bologna, Italy

[2] Alma Mater Studiorum Univ Bologna, Engn Fac 2, Virtual Real & Simulat Lab, Bologna, Italy

[3] Alma Mater Studiorum Univ Bologna, Sect Prosthodont, Dept Oral Sci, Bologna, Italy

来源：

COMPUTERIZED MEDICAL IMAGING AND GRAPHICS | 2009年 / 33卷 / 01期

关键词：

Maxillofacial prosthesis; CAD-CAM; Scaffold; Rapid prototyping; Bone regeneration; TISSUE; BIOLOGY;

D O I：

10.1016/j.compmedimag.2008.10.005

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

We developed a model to test new bone constructs to replace spare skeletal segments originating from new generation scaffolds for bone marrow-derived mesenchymal stem cells. Using computed tomography (CT) data, scaffolds were defined using computer-aided design/computer-aided manufacturing (CAD/CAM) for rapid prototyping by three-dimensional (3D) printing. A bone defect was created in pig mandible ramus by condyle resection for CT and CAD/CAM elaboration of bone volume for cutting and scaffold restoration. The protocol produced a perfect-fitting bone substitute model for rapid prototyped hydroxyapatite (HA) scaffolds. A surgical guide system was developed to accurately reproduce virtually planned bone sectioning procedures in animal models to obtain a perfect fit during surgery. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：58 / 62

页数：5

共 20 条

[1]

Agrawal CM, 2001, J BIOMED MATER RES, V55, P141, DOI 10.1002/1097-4636(200105)55:2<141::AID-JBM1000>3.3.CO

[2]

2-A

[3]

[Anonymous], 1999, Principles of CAD/CAM/CAE Systems

[4]

Customization of load-bearingy hydroxyapatite lattice scaffolds [J].