Seroepidemiology of Hepatitis A Among Greek Children Indicates That the Virus Is Still Prevalent: Implications for Universal Vaccination

被引：21

作者：

Kyrka, A. ^{[1
]}

Tragiannidis, A. ^{[2
]}

Cassimos, D. ^{[3
]}

Pantelaki, K. ^{[4
]}

Tzoufi, M. ^{[5
]}

Mavrokosta, M. ^{[6
]}

Pedeli, X. ^{[7
]}

Athanassiadou, F. ^{[2
]}

Hatzimichael, A. ^{[3
]}

Konstantopoulos, A. ^{[1
]}

Kafetzis, D. ^{[1
]}

Papaevangelou, V. ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Dept Pediat 2, A Kyriakou Childrens Hosp, GR-11527 Athens, Greece

[2] Aristotle Univ Thessaloniki, Sch Med, Dept Pediat 2, GR-54006 Thessaloniki, Greece

[3] Democritus Univ Thrace, Dept Pediat, Alexandroupolis, Greece

[4] A Sophia Childrens Hosp, Blood Bank Lab, Athens, Greece

[5] Univ Ioannina, Sch Med, Dept Pediat, GR-45110 Ioannina, Greece

[6] Venizelos Gen Hosp, Pediat Clin, Iraklion, Crete, Greece

[7] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens 11527, Greece

来源：

JOURNAL OF MEDICAL VIROLOGY | 2009年 / 81卷 / 04期

关键词：

hepatitis A; vaccine; seroepidemiology; UNITED-STATES; CONTROLLED-TRIAL; INFECTION; SEROPREVALENCE; MODELS; ERA;

D O I：

10.1002/jmv.21434

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A national cross-sectional seroprevalence survey was conducted in order to evaluate the current seroepidemiology of hepatitis A among 1,383 children, aged 0-14 years, residing in Greece. Stratification of the study population was conducted according to age and area of residence. Sera from study participants were tested for the presence of anti-HAV IgG antibodies. Immigrant children, as well as children residing in rural areas, had lower immunization rates. Among unvaccinated children, the seroprevalence rate of anti-HAV was 17.1%. Nationality was shown to have a marginally significant effect since non-immunized immigrant children had a higher seroprevalence rate (22.4% vs. 15.9%, OR = 1.52, P = 0.064). Significant differences between geographic areas for both vaccination coverage and natural immunity were observed. The study findings indicate that hepatitis A is prevalent in Greece and therefore universal infant hepatitis A immunization should be implemented. J. Med. Virol. 81:582-587, 2009. (C) 2009 Wiley-Liss, Inc.

引用

页码：582 / 587

页数：6

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