The role of insulin-like growth factor 1 and its receptor in the formation and development of colorectal carcinoma

被引：42

作者：

Zhang, Rong ^{[1
,2
]}

Xu, Guo-Liang ^{[1
,2
]}

Li, Yin ^{[1
,2
]}

He, Long-Jun ^{[1
,2
]}

Chen, Li-Ming ^{[1
,2
]}

Wang, Guo-Bao ^{[1
,2
]}

Lin, Shi-Yong ^{[1
,2
]}

Luo, Guang-Yu ^{[1
,2
]}

Gao, Xiao-Yan ^{[1
,2
]}

Shan, Hong-Bo ^{[1
,2
]}

机构：

[1] State Key Lab Oncol Southern China, Guangzhou, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Ctr Canc, Dept Endoscopy, Guangzhou 510060, Guangdong, Peoples R China

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2013年 / 41卷 / 04期

关键词：

Insulin-like growth factor 1; insulin-like growth factor receptor; colorectal polyps; colorectal carcinoma; quantitative real-time RT-PCR; enzyme-linked immunosorbent assay; FACTOR-I-RECEPTOR; COLON-CANCER CELLS; PROSTATE-CANCER; EXPRESSION; CARCINOGENESIS; KINASE; AXIS; APOPTOSIS; HORMONE; HYPOXIA;

D O I：

10.1177/0300060513487631

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Objective To investigate the role of insulin-like growth factor (IGF)-1 and its receptor (IGF1R) in the formation and development of colorectal carcinoma. Methods Colorectal tissue and matching serum samples were collected from patients with adenomatous polyps or carcinoma and healthy control subjects. IGF1R mRNA levels were determined via quantitative real-time reverse transcription-polymerase chain reaction. Serum IGF1 was quantified using enzyme-linked immunosorbent assay. Results Serum IGF1 concentrations and mucosal IGF1R mRNA levels were significantly higher in patients with adenomatous polyps (n=24) or carcinoma (n=13) compared with healthy control subjects (n=13). There was a significant positive correlation between serum IGF1 and mucosal IGF1R mRNA in patients with adenomatous polyps. Conclusions High circulating IGF1 concentrations and mucosal IGF1R expression may play important roles in both the formation and development of colorectal carcinoma. IGF1 and its receptor may be activated before carcinogenesis, and may promote the growth and malignant transformation of adenomatous polyps. IGF1 and IGF1R may be useful biomarkers for evaluating the stage and risk of carcinogenesis.

引用

页码：1228 / 1235

页数：8

共 41 条

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