Toward a molecular Coulter(R) counter type device

被引:22
作者
Kobayashi, Y [1 ]
Martin, CR [1 ]
机构
[1] COLORADO STATE UNIV,DEPT CHEM,FT COLLINS,CO 80523
来源
JOURNAL OF ELECTROANALYTICAL CHEMISTRY | 1997年 / 431卷 / 01期
基金
美国国家科学基金会; 日本学术振兴会;
关键词
D O I
10.1016/S0022-0728(97)00167-8
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The Coulter(R) counter is a device used to count biological cells and colloidal particles. It consists of a small aperture that separates two electrolyte solutions, one of which contains the particles to be counted. The size or the particle that can be counted is related to the size of the aperture used. We have recently shown that metal nanotubules can be electrolessly plated within the pores of microporous filtration membranes. Tubules with inside diameters that approach molecular dimensions (<2 nm) have been prepared. Because the inside diameter of these nanotubules can be of molecular dimensions, it seemed possible that a Coulter(R)-type device based on the nanotubule membranes might be able to count molecules. If so, this device might provide a new and general approach for determining trace concentrations of molecules in solution. A prototype device was constructed and used to determine the concentrations of the cations Ru(bpy)(3)(2+) (bpy = 2,2-bipyridine) and methylviologen in aqueous solution. Concentrations of Ru(bpy)(3)(2+) as low as 10(-9) M could be detected. (C) 1997 Elsevier Science S.A.
引用
收藏
页码:29 / 33
页数:5
相关论文
共 9 条
[1]   ELECTROKINETIC MEASUREMENTS WITH SUBMICRON PARTICLES AND PORES BY RESISTIVE PULSE TECHNIQUE [J].
DEBLOIS, RW ;
BEAN, CP ;
WESLEY, RKA .
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1977, 61 (02) :323-335
[2]   COUNTING AND SIZING OF SUBMICRON PARTICLES BY RESISTIVE PULSE TECHNIQUE [J].
DEBLOIS, RW ;
BEAN, CP .
REVIEW OF SCIENTIFIC INSTRUMENTS, 1970, 41 (07) :909-&
[3]   SIZES AND CONCENTRATIONS OF SEVERAL TYPE-C ONCORNAVIRUSES AND BACTERIOPHAGE-T2 BY RESISTIVE-PULSE TECHNIQUE [J].
DEBLOIS, RW ;
WESLEY, RKA .
JOURNAL OF VIROLOGY, 1977, 23 (02) :227-233
[4]  
HULTEEN JC, 1997, UNPUB
[5]   NMR studies of single-file diffusion in unidimensional channel zeolites [J].
Kukla, V ;
Kornatowski, J ;
Demuth, D ;
Gimus, I ;
Pfeifer, H ;
Rees, LVC ;
Schunk, S ;
Unger, KK ;
Karger, J .
SCIENCE, 1996, 272 (5262) :702-704
[6]  
LINES RW, 1992, PARTICLE SIZE ANAL
[7]   FABRICATION AND EVALUATION OF NANOELECTRODE ENSEMBLES [J].
MENON, VP ;
MARTIN, CR .
ANALYTICAL CHEMISTRY, 1995, 67 (13) :1920-1928
[8]   METAL NANOTUBULE MEMBRANES WITH ELECTROCHEMICALLY SWITCHABLE ION-TRANSPORT SELECTIVITY [J].
NISHIZAWA, M ;
MENON, VP ;
MARTIN, CR .
SCIENCE, 1995, 268 (5211) :700-702
[9]   CALIBRATED MEMBRANES WITH COATED PORE WALLS [J].
PETZNY, WJ ;
QUINN, JA .
SCIENCE, 1969, 166 (3906) :751-&