Synthesis of 2-arylbenzoxazoles by copper-catalyzed intramolecular oxidative C-O coupling of benzanilides

被引:338
作者
Ueda, Satoshi [1 ]
Nagasawa, Hideko [1 ]
机构
[1] Gifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5028585, Japan
基金
日本学术振兴会;
关键词
C-H activation; C-O bond formation; copper; homogeneous catalysis; nitrogen heterocycles;
D O I
10.1002/anie.200801240
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(Chemical Equation Presented) No need for additives: A wide variety of functionalized 2-arylbenzoxazoles can be prepared with high functional-group tolerance and regioselectivity by a copper-catalyzed intramolecular oxidative C-O coupling of benzanilides. The catalytic cycle is completed by the regeneration of the copper catalyst using molecular oxygen as a terminal oxidant without the need for additives. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:6411 / 6413
页数:3
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