The pharmacokinetics of factor VIII and factor IX: Methodology, pitfalls and applications

被引：50

作者：

Bjorkman, S ^{[1
]}

Carlsson, M ^{[1
]}

机构：

[1] MALMO UNIV HOSP, DEPT COAGULAT DISORDERS, S-20502 MALMO, SWEDEN

来源：

HAEMOPHILIA | 1997年 / 3卷 / 01期

关键词：

comparative studies; dosing; factor VIII; factor IX; methodological aspects; pharmacokinetics;

D O I：

10.1046/j.1365-2516.1997.00074.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This article reviews the pharmacokinetics of exogenous factor VIII and factor IX in patients with haemophilia. It focuses on the methodology (and inherent pitfalls) of pharmacokinetic studies, then summarizes available pharmacokinetic data and finally discusses some applications of pharmacokinetics for optimization of prophylactic treatment of haemophilia and for comparison of coagulation factor concentrates.

引用

页码：1 / 8

页数：8

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