Cerebrovascular evidence for a GABAergic modulation of the cholinergic vasodilatatory basalocortical system in the rat

被引：8

作者：

Barbelivien, A ^{[1
]}

Noël, C ^{[1
]}

MacKenzie, ET ^{[1
]}

Dauphin, F ^{[1
]}

机构：

[1] Univ Caen, CNRS, UMR 6551, Cyceron, F-14074 Caen, France

来源：

BRAIN RESEARCH | 1999年 / 834卷 / 1-2期

关键词：

acetylcholine; cerebral blood flow; cholinergic system; GABA; rat; substantia innominata;

D O I：

10.1016/S0006-8993(99)01597-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present work is aimed to study the functional relevance of GABAergic-cholinergic interactions on the modulation of cerebral blood flow (CBF) exerted by the basalocortical system. Injections of GABA into the substantia innominata (SI) induce increases in blood flow in several cortical areas and inhibit partly the increases in cortical blood flow induced by cholinergic activation of this structure. Blockade of local GABAergic receptors by picrotoxin induced almost similar effects. These findings suggest that local GABAergic neurones of the SI exert a complex cortical cerebrovascular modulation at a resting and an activated state. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：223 / 227

页数：5

共 27 条

[1] Autoradiographic mapping of cerebral blood flow responses to cholinergic stimulation of the rat substantia innominata: modulatory effect of galanin [J].

Barbelivien, A ;

MacKenzie, ET ;

Dauphin, F .

BRAIN RESEARCH, 1998, 789 (01) :92-100

[2] REGIONAL CEREBRAL BLOOD-FLOW RESPONSES TO NEUROCHEMICAL STIMULATION OF THE SUBSTANTIA INNOMINATA IN THE ANESTHETIZED RAT [J].

BARBELIVIEN, A ;

MACKENZIE, ET ;

DAUPHIN, F .

NEUROSCIENCE LETTERS, 1995, 190 (02) :81-84

[3] GALANIN INHIBITS THE VASOLILATATORY BASALOCORTICAL CHOLINERGIC SYSTEM IN THE ANESTHETIZED RAT [J].

BARBELIVIEN, A ;

MACKENZIE, ET ;

DAUPHIN, F .

NEUROREPORT, 1995, 6 (14) :1849-1852

[4] STIMULATION OF THE NUCLEUS BASALIS OF MEYNERT INCREASES CEREBRAL CORTICAL BLOOD-FLOW IN RATS [J].

BIESOLD, D ;

INANAMI, O ;

SATO, A ;

SATO, Y .

NEUROSCIENCE LETTERS, 1989, 98 (01) :39-44

[5] HYPERCAPNIA AND STIMULATION OF THE SUBSTANTIA INNOMINATA INCREASE RAT FRONTAL CORTICAL BLOOD-FLOW BY DIFFERENT CHOLINERGIC MECHANISMS [J].

DAUPHIN, F ;

LACOMBE, P ;

SERCOMBE, R ;

HAMEL, E ;

SEYLAZ, J .

BRAIN RESEARCH, 1991, 553 (01) :75-83

[6] STIMULATION OF GABA(B) RECEPTORS IN THE BASAL FOREBRAIN SELECTIVELY IMPAIRS WORKING-MEMORY OF RATS IN THE DOUBLE Y-MAZE [J].

DESOUSA, NJ ;

BENINGER, RJ ;

JHAMANDAS, K ;

BOEGMAN, RJ .

BRAIN RESEARCH, 1994, 641 (01) :29-38

[7] Differential interaction between 5-HT3 receptors and GABAergic neurons inhibiting acetylcholine release in rat entorhinal cortex slices [J].

Díez-Ariza, M ;

Ramírez, MJ ;

Lasheras, B ;

Del Río, J .

BRAIN RESEARCH, 1998, 801 (1-2) :228-232

[8] GABAergic regulation of cerebral microvascular tone in the rat [J].

Fergus, A ;

Lee, KS .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1997, 17 (09) :992-1003

[9] GAMMA-AMINOBUTYRIC ACID-CONTAINING BASAL FOREBRAIN NEURONS INNERVATE INHIBITORY INTERNEURONS IN THE NEOCORTEX [J].

FREUND, TF ;

MESKENAITE, V .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (02) :738-742

[10]

Gritti I, 1997, J COMP NEUROL, V383, P163

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