Growth factors and cytokines in pancreatic carcinogenesis

被引:58
作者
Friess, H [1 ]
Guo, XZ [1 ]
Nan, BC [1 ]
Kleeff, Ö [1 ]
Büchler, MW [1 ]
机构
[1] Univ Bern, Dept Visceral & Transplantat Surg, Inselspital, CH-3010 Bern, Switzerland
来源
CELL AND MOLECULAR BIOLOGY OF PANCREATIC CARCINOMA: RECENT DEVELOPMENTS IN RESEARCH AND EXPERIMENTAL THERAPY | 1999年 / 880卷
关键词
D O I
10.1111/j.1749-6632.1999.tb09515.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Pancreatic cancer is a deadly disease challenging basic and clinical researchers alike in characterizing its pathobiology and finding better treatment options. A number of molecular alterations including gene, mutations such as k-rasi p53, and Smad4 and aberrant expression of a-variety-of genes have been identified in recent years. This review focuses: on two families of growth factors and growth factor receptors which are representative for the molecular alterations observed in pancreatic cancer: the transforming \growth factor-beta superfamily of serine-threonine kinase receptors. and their ligands, which usually act as negative growth regulators, and the epidermal growth fac- tor receptor family and their ligands, which have the potential to act as growth promoters in pancreatic cancer. In addition, we will discuss the role of the cytokines TMF-alpha, IFN-gamma, and IL-6 and its effects on pancreatic cancer cell proliferation in vitro and in vivo; Pancreatic cancer cell biology consists of complex interactions, of various factors,, and a better understanding df the molecular pathogenesis of this disorder might had to better treatment strategies in the near future.
引用
收藏
页码:110 / 121
页数:12
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