Selection bias in evaluating of influenza vaccine effectiveness: A lesson from an observational study of elderly nursing home residents

被引：9

作者：

Fukushima, Wakaba ^{[1
]}

Hayashi, Yoshimitsu ^{[2
]}

Mizuno, Yaichi ^{[2
]}

Suzuki, Kanzo ^{[3
]}

Kase, Tetsuo ^{[4
]}

Ohfuji, Satoko ^{[1
]}

Fujieda, Megumi ^{[1
]}

Maeda, Akiko ^{[1
]}

Hirota, Yoshio ^{[1
]}

机构：

[1] Osaka City Univ, Fac Med, Dept Publ Hlth, Abeno Ku, Osaka 5458585, Japan

[2] Nagoya Shi Kouseiin Med Welf Ctr, Meito Ku, Nagoya, Aichi 4658610, Japan

[3] Minato Publ Hlth Ctr, Minato Ku, Nagoya, Aichi 4550015, Japan

[4] Osaka Prefectural Inst Publ Hlth, Dept Infect Dis, Higashinari Ku, Osaka 5370025, Japan

来源：

VACCINE | 2008年 / 26卷 / 50期

关键词：

Influenza; Vaccine effectiveness; Bias;

D O I：

10.1016/j.vaccine.2008.06.038

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Selection bias is of critical concern in the study of influenza vaccine effectiveness when using an observational study design. This bias is attributable to the inherently different characteristics between vaccinees and non-vaccinees. The differences, which are related both to vaccination and signs of clinical disease as an outcome, may lead to erroneous estimation of the effectiveness. In this report, we describe how selection bias among elderly nursing home residents may lead to a spurious interpretation of the protective effect of influenza vaccine. Our results should be a lesson in the importance of regarding selection bias when assessing influenza vaccine effectiveness. (C) 2008 Elsevier Ltd. All rights reserved

引用

页码：6466 / 6469

页数：4

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