The cytolethal distending toxin of Haemophilus ducreyi inhibits endothelial cell proliferation

被引：15

作者：

Svensson, LA ^{[1
]}

Henning, P ^{[1
]}

Lagergård, T ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Med Microbiol & Immunol, S-4136 Gothenburg, Sweden

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 05期

关键词：

D O I：

10.1128/IAI.70.5.2665-2669.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Haemophilus ducreyi, the etiologic agent of the sexually transmitted disease chancroid, produces a cytolethal distending toxin (HdCDT) that inhibits mammalian cell proliferation. We investigated the effects of HdCDT on normal human endothelial cells and on tubule formation in an in vitro model of angiogenesis. Endothelial cells were arrested in the G(2) phase of the cell cycle, and tubule formation was inhibited in a dose-dependent manner. The anti proliferative activities of HdCDT on endothelial cells might contribute to the characteristic slow healing and persistence of chancroid ulcers.

引用

页码：2665 / 2669

页数：5

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