Intrinsic and extrinsic modulation of nitric oxide synthase activity

被引：177

作者：

Roman, LJ

Martásek, P

Masters, BSS

机构：

[1] Univ Texas, Hlth Sci Ctr, Dept Biochem, San Antonio, TX 78229 USA

[2] Charles Univ Prague, Fac Med 1, Ctr Integrat Genom, Dept Pediat, Prague 12109, Czech Republic

来源：

CHEMICAL REVIEWS | 2002年 / 102卷 / 04期

关键词：

D O I：

10.1021/cr000661e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The NOS isoforms are modulated by a precise symphony of both intrinsic and extrinsic factors. The overall rate of NO production by each of the isoforms is finely tuned by an amazingly complex combination of intrinsic factors, including the heme environment, and dimerization state, CaM binding, the autoinhibitory domain, and the C-terminal tail region, and extrinsic factors, such as posttranslational modifications, phosphorylation, and specific interactions with other proteins.

引用

收藏

页码：1179 / 1189

页数：11

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