MicroRNAs regulate both epithelial-to-mesenchymal transition and cancer stem cells

被引：96

作者：

Ceppi, P. ^{[1
]}

Peter, M. E. ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

ONCOGENE | 2014年 / 33卷 / 03期

关键词：

miRNAs; epithelial-to-mesenchymal transition; cancer stem cells; E-CADHERIN EXPRESSION; HUMAN OVARIAN-CANCER; DRUG-RESISTANCE; MIR-200; FAMILY; ALDEHYDE DEHYDROGENASE; PROSTATE-CANCER; DOWN-REGULATION; STEM/PROGENITOR CELLS; UNFAVORABLE PROGNOSIS; DYNAMIC EQUILIBRIUM;

D O I：

10.1038/onc.2013.55

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Concepts and experimental models derived from basic research have been successfully applied to the field of molecular oncology, tremendously increasing our knowledge of the nature and the progression of tumors. The process of epithelial-to-mesenchymal transition, the cancer stem cell hypothesis, and their functional association and interdependence represent some of the most significant examples. The molecular determinants underlying the plasticity of cancers are currently the object of extensive research efforts, and a substantial body of evidence suggests that these models can be connected by the regulatory role of microRNAs, small noncoding RNA molecules with a fundamental role in many cellular functions. This review will highlight and discuss this link and its possible implications for the fight against cancer.

引用

页码：269 / 278

页数：10

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