Intracytoplasmic sperm injection pregnancy with trisomy 20p and monosomy 22q in a newborn resulting from a balanced paternal translocation

被引：9

作者：

Belin, V ^{[1
]}

Farhat, M ^{[1
]}

Monset-Couchard, M ^{[1
]}

机构：

[1] Univ Paris 05, CHU Cochin Port Royal, Port Royal Neonatal Intens Care Unit, F-75679 Paris, France

来源：

BIOLOGY OF THE NEONATE | 1999年 / 75卷 / 06期

关键词：

intracytoplasmic sperm injection; chromosome abnormality; translocation; trisomy; 20; monosomy; 22; triplet pregnancy;

D O I：

10.1159/000014121

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

In infertile men who carry a balanced reciprocal translocation, intracytoplasmic sperm injection (ICSI) may induce a pregnancy with an abnormal karyotype. This report describes a previously unreported paternal reciprocal translocation leading to a chromosomally unbalanced ICSI pregnancy, The triplet pregnancy resulted in 1 normal girl, 1 physically normal boy with the same balanced paternal translocation, and a severely malformed boy with trisomy 20p and monosomy 22q who died in the neonatal period.

引用

页码：398 / 401

页数：4

共 24 条

[1]

Baschat AA, 1996, HUM REPROD, V11, P926

[2] Genetic disorders in normally androgenized infertile men and the use of intracytoplasmic sperm injection as a way of treatment [J].