Structure and reactivity of the metal centers of ribonucleotide reductases

被引：7

作者：

Mulliez, E

Fontecave, M

机构：

[1] Laboratoire d'Etudes Dynamiques, Structurales de la Sélectivité, UMR CNRS Université, Joseph Fourier

来源：

CHEMISCHE BERICHTE-RECUEIL | 1997年 / 130卷 / 03期

关键词：

ribonucleotide reductase; tyrosyl radical; adenosyl radical; glycyl radical; iron-sulfur cluster; cobalamin; (S)-adenosyl methionine;

D O I：

10.1002/cber.19971300303

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The activation of the three classes of ribonucleotide reductases as free radical enzymes is reviewed. Class I uses O-2 and a diferric mu-oxo center to generate a stable tyrosyl protein radical. Class II operates with adenosyl cobalamin as the precursor of a putative transient thiyl protein radical. Class III forms an O-2-sensitive protein glycyl radical by the concerted action of an iron-sulfur cluster and (S)-adenosyl methionine.

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页码：317 / +

页数：1

相关论文

共 42 条

[1]

ABERG A, 1993, BIOCHEMISTRY-US, V32, P9845

[2] PASSAGE FROM CONCERTED TO STEPWISE DISSOCIATIVE ELECTRON-TRANSFER AS A FUNCTION OF THE MOLECULAR-STRUCTURE AND OF THE ENERGY OF THE INCOMING ELECTRON - ELECTROCHEMICAL REDUCTION OF ARYLDIALKYL SULFONIUM CATIONS [J].

ANDRIEUX, CP ;

ROBERT, M ;

SAEVA, FD ;

SAVEANT, JM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (17) :7864-7871

[3] FLAVODOXIN IS REQUIRED FOR THE ACTIVATION OF THE ANAEROBIC RIBONUCLEOTIDE REDUCTASE [J].

BIANCHI, V ;

ELIASSON, R ;

FONTECAVE, M ;

MULLIEZ, E ;

HOOVER, DM ;

MATTHEWS, RG ;

REICHARD, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 197 (02) :792-797

[4] MECHANISM OF ASSEMBLY OF THE TYROSYL RADICAL-DIIRON(III) COFACTOR OF ESCHERICHIA-COLI RIBONUCLEOTIDE REDUCTASE .2. KINETICS OF THE EXCESS FE2+ REACTION BY OPTICAL, EPR, AND MOSSBAUER SPECTROSCOPIES [J].

BOLLINGER, JM ;

TONG, WH ;

RAVI, N ;

HUYNH, BH ;

EDMONDSON, DE ;

STUBBE, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (18) :8015-8023

[5] MECHANISM OF ASSEMBLY OF THE TYROSYL RADICAL DINUCLEAR IRON CLUSTER COFACTOR OF RIBONUCLEOTIDE REDUCTASE [J].

BOLLINGER, JM ;

EDMONDSON, DE ;

HUYNH, BH ;

FILLEY, J ;

NORTON, JR ;

STUBBE, J .

SCIENCE, 1991, 253 (5017) :292-298

[6] COENZYME-B-12 DEPENDENT RIBONUCLEOTIDE REDUCTASE - EVIDENCE FOR THE PARTICIPATION OF 5 CYSTEINE RESIDUES IN RIBONUCLEOTIDE REDUCTION [J].

BOOKER, S ;

LICHT, S ;

BRODERICK, J ;

STUBBE, J .

BIOCHEMISTRY, 1994, 33 (42) :12676-12685

[7] Rapid freeze-quench ENDOR of the radical X intermediate of Escherichia coli ribonucleotide reductase using O-17(2), (H2O)-O-17, and (H2O)-H-2 [J].

Burdi, D ;

Sturgeon, BE ;

Tong, WH ;

Stubbe, JA ;

Hoffman, BM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (01) :281-282

[8]

DERONZIER C, UNPUB

[9] AN EXCHANGE-COUPLED COMPLEX WITH LOCALIZED HIGH-SPIN FE-IV AND FE-III SITES OF RELEVANCE TO CLUSTER-X OF ESCHERICHIA-COLI RIBONUCLEOTIDE REDUCTASE [J].

DONG, YH ;

QUE, L ;

KAUFFMANN, K ;

MUNCK, E .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (45) :11377-11378

[10]

ELIASSON R, 1994, J BIOL CHEM, V269, P26052

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