Establishment and functioning of intrathymic microenvironments

被引：84

作者：

Anderson, G ^{[1
]}

Jenkinson, WE ^{[1
]}

Jones, T ^{[1
]}

Parnell, SM ^{[1
]}

Kinsella, FAM ^{[1
]}

White, AJ ^{[1
]}

Pongrac'z, JE ^{[1
]}

Rossi, SW ^{[1
]}

Jenkinson, EJ ^{[1
]}

机构：

[1] Univ Birmingham, Inst Biomed Res, Sch Med, MRC Ctr Immune Regulat,Div Immunity & Infect, Birmingham B15 2TT, W Midlands, England

来源：

IMMUNOLOGICAL REVIEWS | 2006年 / 209卷

基金：

英国医学研究理事会;

关键词：

D O I：

10.1111/j.0105-2896.2006.00347.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The thymus supports the production of self-tolerant T cells from immature precursors. Studying the mechanisms regulating the establishment and maintenance of stromal microenvironments within the thymus therefore is essential to our understanding of T-cell production and ultimately immune system functioning. Despite our ability to phenotypically define stromal cell compartments of the thymus, the mechanisms regulating their development and the ways by which they influence T-cell precursors are still unclear. Here, we review recent findings and highlight unresolved issues relating to the development and functioning of thymic stromal cells.

引用

页码：10 / 27

页数：18

共 184 条

[1] Dependence of self-tolerance on TRAF6-directed development of thymic stroma [J].