beta AP deposition and head trauma

被引：21

作者：

AdleBiassette, H ^{[1
]}

Duyckaerts, C ^{[1
]}

Wasowicz, M ^{[1
]}

He, Y ^{[1
]}

Fornes, P ^{[1
]}

Foncin, JF ^{[1
]}

Lecomte, D ^{[1
]}

Hauw, JJ ^{[1
]}

机构：

[1] INST MEDICOLEGAL PARIS, F-75012 PARIS, FRANCE

来源：

NEUROBIOLOGY OF AGING | 1996年 / 17卷 / 03期

关键词：

beta AP diffuse deposits; head trauma; Alzheimer's disease; senile plaques;

D O I：

10.1016/0197-4580(96)00029-2

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Head trauma is considered to be a risk factor for Alzheimer's disease, because a high prevalence of beta AP deposits has repeatedly been reported in patients who died within a few days following head injury. To evaluate this statement, we undertook two studies using immunohistochemistry for beta AP and found a surprisingly low prevalence of beta AP diffuse deposits. We first selected 23 patients aged 17-63 years, who died 0-76 days after head trauma. Using beta AP antibody at the usual dilution (1:100), we did not find any deposits. With a high concentration of antibody (dilution 1:2) we found beta AP diffuse deposits in one 46-year-old case. In a second study, 17 patients aged 60-79 years old, who died 1-35 days after head injury, were compared to a control group. We did not find any significant difference in the density of beta AP diffuse deposits between cases and controls using usual dilutions of beta AP antibody. The density of beta AP diffuse deposits was linked only to aging and the presence of senile plaques.

引用

页码：415 / 419

页数：5

共 28 条

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