Frequent IDH1/2 mutations in intracranial chondrosarcoma: a possible diagnostic clue for its differentiation from chordoma

被引：75

作者：

Arai, Motohiro ^{[1
]}

Nobusawa, Sumihito ^{[1
]}

Ikota, Hayato ^{[1
]}

Takemura, Sunao ^{[2
]}

Nakazato, Yoichi ^{[1
]}

机构：

[1] Gunma Univ, Grad Sch Med, Dept Human Pathol, Maebashi, Gunma 3718511, Japan

[2] Yamagata Univ, Fac Med, Dept Neurosurg, Yamagata 9909585, Japan

来源：

BRAIN TUMOR PATHOLOGY | 2012年 / 29卷 / 04期

关键词：

Isocitrate dehydrogenase; Mutation; Chondrosarcoma; Chordoma; IDH2; MUTATIONS;

D O I：

10.1007/s10014-012-0085-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Mutations in the genes encoding isocitrate dehydrogenase (IDH) 1/2 have been detected in a significant proportion of diffuse gliomas and in a small fraction of acute myeloid leukemia (AML) cases. Recently, in an examination of various types of mesenchymal tumor, IDH1/2 mutations were only found in cartilaginous tumors including central conventional and periosteal enchondromas/chondrosarcomas. The frequency of IDH1/2 mutations was 56%, and the IDH1 R132C mutation, which is not common in diffuse gliomas or AML, accounted for 40% of these mutations. In this study, we investigated the IDH1/2 mutation status of intracranial chondrosarcomas and chordomas, which are morphologically similar and affect similar regions of the cranial cavity. Of the 13 chondrosarcomas analyzed, six (46.1%) displayed IDH1/2 mutations (the predominant type was IDH1 R132C). Also, an IDH2 mutation (R172S) was observed in one case. Conversely, none of the ten chordomas analyzed displayed any IDH1 or IDH2 mutations. Our data suggest that the IDH1/2 mutation status could be valuable for distinguishing intracranial chondrosarcomas from chordomas.

引用

页码：201 / 206

页数：6

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