The protein phosphatase 2C (PP2C) superfamily: Detection of bacterial homologues

被引：169

作者：

Bork, P ^{[1
]}

Brown, NP ^{[1
]}

Hegyi, H ^{[1
]}

Schultz, J ^{[1
]}

机构：

[1] MAX DELBRUCK CTR MOLEC MED,BERLIN,GERMANY

来源：

PROTEIN SCIENCE | 1996年 / 5卷 / 07期

关键词：

alignment; bacterial serine/threonine phosphatases; homology search; PP2C; SpoIIE;

D O I：

10.1002/pro.5560050720

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A thorough sequence analysis of the various members of the eukaryotic protein serine/threonine phosphatase 2C (PP2C) family revealed the conservation of 11 motifs. These motifs could be identified in numerous other sequences, in eluding fungal adenylate cyclases that are predicted to contain a functionally active PP2C domain, and a family of prokaryotic serine/threonine phosphatases including SpoIIE. Phylogenetic analysis of all the proteins indicates a widespread sequence family for which a considerable number of isoenzymes can be inferred.

引用

页码：1421 / 1425

页数：5

共 32 条

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