The somatostatin sst1 receptor:: An autoreceptor for somatostatin in brain and retina?

被引：40

作者：

Thermos, Kyriaki

Bagnoli, Paola

Epelbaum, Jacques

Hoyer, Daniel ^{[1
]}

机构：

[1] Novartis Pharma AG, Novartis Inst Biomed Res, Neurosci Res, CH-4002 Basel, Switzerland

[2] Univ Crete, Sch Med, Dept Basic Sci, Pharmacol Lab, GR-71110 Iraklion, Greece

[3] Univ Pisa, Dipartimento Fisiol & Biochim G Moruzzi, I-56127 Pisa, Italy

[4] Univ Paris Descartes Umr, INSERM, F-75014 Paris, France

[5] Scripps Res Inst, Dept Neuropharmacol, Harold L Dorris Neurol Res Ctr, La Jolla, CA 92037 USA

来源：

PHARMACOLOGY & THERAPEUTICS | 2006年 / 110卷 / 03期

关键词：

somatostatinsst; receptorsBasal gangliaHippocampusHypothalamusRetina;

D O I：

10.1016/j.pharmthera.2005.09.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The sst(1) receptor was the first of the 5 somatostatin receptors to be cloned by homology with the glucagon receptor 13 years ago. It is a 7-transmembrane domain G-protein-coupled receptor that is negatively coupled to adenylyl cyclase, but can also trigger other transduction pathways. The distribution of sst(1) mRNA, immunolabeling, and radioligand binding are not entirely overlapping, but the recent availability of knockout (KO) mice and a (still limited) number of selective agonists/antagonists has increased our knowledge about this receptor. These new tools have helped to reveal a role for the sst(1) receptor in hippocampal, hypothalamic, basal ganglia, and retinal functions. In at least the latter 3 structures, the sst(1) receptor appears to act as an inhibitory autoreceptor located on somatostatin neurons, whereas in the hippocampus such a role is still based on circumstantial evidence. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：455 / 464

页数：10

共 97 条

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