Thiazolidinedione inhibits the production of monocyte chemoattractant protein-1 in cytokine-treated human vascular endothelial cells

被引：72

作者：

Murao, K ^{[1
]}

Imachi, H ^{[1
]}

Momoi, A ^{[1
]}

Sayo, Y ^{[1
]}

Hosokawa, H ^{[1
]}

Sato, M ^{[1
]}

Ishida, T ^{[1
]}

Takahara, J ^{[1
]}

机构：

[1] Kagawa Med Univ, Dept Internal Med 1, Miki, Kagawa 7610793, Japan

来源：

FEBS LETTERS | 1999年 / 454卷 / 1-2期

关键词：

monocyte chemoattractant protein-1; thiazolidinedione; interleukin-1; beta; tumor necrosis factor-alpha; human vascular endothelial cell;

D O I：

10.1016/S0014-5793(99)00765-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chemokine monocyte chemoattractant protein-1 is a potent chemoattractant for monocytes. Monocyte chemoattractant protein-1 is produced by vascular endothelial cells during inflammatory diseases such as atherosclerosis, In this study, we examined the effects of a thiazolidinedione on monocyte chemoattractant protein-1 expression in human vascular endothelial cells. In human vascular endothelial cells, interleukin-1 beta and tumor necrosis factor-alpha induced endogenous monocyte chemoattractant protein-1 protein secretion, mRNA expression and promoter activity. The thiazolidinedione inhibited these effects. In summary, our results indicated that the suppression of the expression of monocyte chemoattractant protein-1 can be accomplished by thiazolidinedione treatment, raising the possibility that thiazolidinedione may be of therapeutic value in the treatment of diseases such as atherosclerosis, (C) 1999 Federation of European Biochemical Societies.

引用

页码：27 / 30

页数：4

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