Sphingosine 1-phosphate regulates heat shock protein 27 induction by a p38 MAP kinase-dependent mechanism in aortic smooth muscle cells

被引:37
作者
Kozawa, O [1 ]
Tanabe, K
Ito, H
Matsuno, H
Niwa, M
Kato, K
Uematsu, T
机构
[1] Gifu Univ, Sch Med, Dept Pharmacol, Gifu 5008705, Japan
[2] Aichi Human Serv Ctr, Inst Dev Res, Dept Biochem, Aichi 4800392, Japan
关键词
sphingosine; 1-phosphate; heat shock protein; mitogen-activated protein kinase; aortic smooth muscle cells; A10; cells;
D O I
10.1006/excr.1999.4536
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In an aortic smooth muscle cell line, A10 cells, we investigated the effect of sphingosine 1-phosphate on the induction of heat shock protein 27 (HSP27), a low-molecular-weight heat shock protein. Sphingosine 1-phosphate significantly induced the accumulation of HSP27 in a pertussis toxin-sensitive manner. The effect was dose-dependent in the range between 0.1 and 30 mu M. Sphingosine 1-phosphate stimulated an increase in the levels of mRNA for HSP27. Sphingosine 1-phosphate stimulated both p42/p44 mitogen-activated protein (MAP) kinase and p38 MAP kinase activation. PD98059, an inhibitor of the upstream kinase that activates p42/p44 MAP kinase, did not affect sphingosine 1-phosphate-stimulated HSP27 induction. In contrast, SB203580, an inhibitor of p38 MAP kinase, reduced sphingosine 1-phosphate-induced HSP27 induction. SB203580 reduced the levels of mRNA for HSP27 induced by sphingosine 1-phosphate. These results indicate that sphingosine 1-phosphate stimulates the induction of HSP27 via p38 MAP kinase activation in aortic smooth muscle cells. (C) 1999 Academic Press.
引用
收藏
页码:376 / 380
页数:5
相关论文
共 31 条
[1]   PD-098059 IS A SPECIFIC INHIBITOR OF THE ACTIVATION OF MITOGEN-ACTIVATED PROTEIN-KINASE KINASE IN-VITRO AND IN-VIVO [J].
ALESSI, DR ;
CUENDA, A ;
COHEN, P ;
DUDLEY, DT ;
SALTIEL, AR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (46) :27489-27494
[2]  
ANG D, 1991, J BIOL CHEM, V266, P24233
[3]  
BENNDORF R, 1994, J BIOL CHEM, V269, P20780
[4]   SPHINGOSINE-1-PHOSPHATE INHIBITS PDGF-INDUCED CHEMOTAXIS OF HUMAN ARTERIAL SMOOTH-MUSCLE CELLS - SPATIAL AND TEMPORAL-MODULATION OF PDGF CHEMOTACTIC SIGNAL-TRANSDUCTION [J].
BORNFELDT, KE ;
GRAVES, LM ;
RAINES, EW ;
IGARASHI, Y ;
WAYMAN, G ;
YAMAMURA, S ;
YATOMI, Y ;
SIDHU, JS ;
KREBS, EG ;
HAKOMORI, S ;
ROSS, R .
JOURNAL OF CELL BIOLOGY, 1995, 130 (01) :193-206
[5]   ERKS - A FAMILY OF PROTEIN-SERINE THREONINE KINASES THAT ARE ACTIVATED AND TYROSINE PHOSPHORYLATED IN RESPONSE TO INSULIN AND NGF [J].
BOULTON, TG ;
NYE, SH ;
ROBBINS, DJ ;
IP, NY ;
RADZIEJEWSKA, E ;
MORGENBESSER, SD ;
DEPINHO, RA ;
PANAYOTATOS, N ;
COBB, MH ;
YANCOPOULOS, GD .
CELL, 1991, 65 (04) :663-675
[6]   BIOLOGICAL AND CLINICAL IMPLICATIONS OF HEAT-SHOCK PROTEIN 27000 (HSP27) - A REVIEW [J].
CIOCCA, DR ;
OESTERREICH, S ;
CHAMNESS, GC ;
MCGUIRE, WL ;
FUQUA, SAW .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (19) :1558-1570
[7]  
COOPER LF, 1994, J BIOL CHEM, V269, P7869
[8]   PHOSPHOLIPID SIGNALING [J].
DIVECHA, N ;
IRVINE, RF .
CELL, 1995, 80 (02) :269-278
[9]   A SYNTHETIC INHIBITOR OF THE MITOGEN-ACTIVATED PROTEIN-KINASE CASCADE [J].
DUDLEY, DT ;
PANG, L ;
DECKER, SJ ;
BRIDGES, AJ ;
SALTIEL, AR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (17) :7686-7689
[10]   MOLECULAR CHAPERONES [J].
ELLIS, RJ ;
VANDERVIES, SM .
ANNUAL REVIEW OF BIOCHEMISTRY, 1991, 60 :321-347