A lipophilic thioflavin-T derivative for positron emission tomography (PET) Imaging of amyloid in brain

被引：308

作者：

Mathis, CA ^{[1
]}

Bacskai, BJ

Kajdasz, ST

McLellan, ME

Frosch, MP

Hyman, BT

Holt, DP

Wang, YM

Huang, GF

Debnath, ML

Klunk, WE

机构：

[1] Univ Pittsburgh, Dept Radiol, PET Facil, Pittsburgh, PA 15213 USA

[2] Massachusetts Gen Hosp, Alzheimers Res Unit, Charlestown, MA 02129 USA

[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA

[4] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(01)00734-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a new lipophilic thioflavin-T analogue (2-[4'-(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [C-11]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposits were imaged with multiphoton microscopy in the brains of living transgenic mice following the systemic injection of unlabeled 6. [C-11]6 is a promising amyloid imaging agent for Alzheimer's disease. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：295 / 298

页数：4

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