Hepatocellular carcinoma and hepatitis B virus

被引：226

作者：

Chan, HLY ^{[1
]}

Sung, JJY ^{[1
]}

机构：

[1] Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China

来源：

SEMINARS IN LIVER DISEASE | 2006年 / 26卷 / 02期

基金：

美国国家卫生研究院;

关键词：

hepatitis B virus; hepatocellular carcinoma; gene; mutation; DNA;

D O I：

10.1055/s-2006-939753

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Chronic hepatitis B is the most common cause of hepatocellular carcinoma (HCC) in Asia. Integration of hepatitis B virus (HBV) genome is likely an early event of carcinogenesis. The integrated HBV genome may activate neighboring cellular genes directly to offer a selective growth advantage to the liver cells. Production of hepatitis B X protein can act as a transactivator on various cellular genes for tumor development. Hepatic inflammation and cirrhosis also favors the process of carcinogenesis. Various viral factors associated with hepatocellular carcinoma development include HBV genotype, basal core promoter mutations, and high viral load. Polymorphisms at the androgen receptor-regulating genes and cytokine genes are possible host factors associated With HCC. This review article summarizes the pathogenesis of HBV-related carcinogenesis and the viral and host factors that may increase the risk of HCC development.

引用

页码：153 / 161

页数：9

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