Anti-diabetic properties of non-polar Toona sinensis Roem extract prepared by supercritical-CO2 fluid

被引：39

作者：

Hsieh, Tusty-Jiuan ^{[2
]}

Tsai, Yi-Hong ^{[1
,3
]}

Liao, Min-Chun ^{[2
]}

Du, Ying-Chi ^{[1
,3
]}

Lien, Pei-Jung ^{[4
]}

Sun, Chuan-Chia ^{[4
]}

Chang, Fang-Rong ^{[1
,3
]}

Wu, Yang-Chang ^{[5
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 80708, Taiwan

[2] Kaohsiung Med Univ, Dept Med Genet, Coll Med, Kaohsiung 80708, Taiwan

[3] Kaohsiung Med Univ, Res & Dev Ctr Chinese Herbal Med & New Drugs, Kaohsiung 80708, Taiwan

[4] Met Ind Res & Dev Ctr, Kaohsiung 811, Taiwan

[5] China Med Univ, Coll Chinese Med, Sch Chinese Med, Taichung 40402, Taiwan

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2012年 / 50卷 / 3-4期

关键词：

Adipocyte; Insulin resistance; Hepatosteatosis; Adiponectin; Phytol; CARBON-DIOXIDE; SAFETY EVALUATION; MEDICINAL-PLANTS; CO2; EXTRACTION; PPAR-ALPHA; MODEL; RAT; APOPTOSIS; SOLVENTS; GLUCOSE;

D O I：

10.1016/j.fct.2011.12.023

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Toona sinensis Roem (T. sinensis) leaves have been used as a nutritious vegetable and been suggested for medical applications: however, the reported bioactive compounds of T. sinensis leaves are, so far, from high to mid-high polar extracts. Our aims in this study were to reveal the non-polar constituents of the T. sinensis leave extract that were prepared by a method of using a supercritical-CO2 fluid and to investigate the anti-diabetic potential of this extract. Through a GC/MS analysis, we revealed 24 major components of the non-polar T. sinensis leave extract, the most abundant of which was phytol. The non-polar T. sinensis leave extract showed to prevent the progression of diabetes and hepatosteatosis, the rise of triglycerol levels and the decrease of adiponectin levels in the type 2 diabetic mice. Our results suggest that the non-polar extract of T. sinensis leaves prepared using the supercritical-CO2 fluid may contain effective constituents to prevent type 2 diabetes. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：779 / 789

页数：11

共 45 条

[1]

Adams R., 2001, Identification of essential oil components by gas chromatography/quadrupole mass spectrometry

[2] Current Antihyperglycemic Treatment Guidelines and Algorithms for Patients with Type 2 Diabetes Mellitus [J].

Blonde, Lawrence .

AMERICAN JOURNAL OF MEDICINE, 2010, 123 :S12-S18

[3] The fractionated Toona sinensis leaf extract induces apoptosis of human ovarian cancer cells and inhibits tumor growth in a murine xenograft model [J].

Chang, Hsueh-Ling ;

Hsu, Hseng-Kuang ;

Su, Jinu-Huang ;

Wang, Pei-Hui ;

Chung, Yueh-Fang ;

Chia, Yi-Chen ;

Tsai, Li-Yu ;

Wu, Yang-Chang ;

Yuan, Shyng-Shiou F. .

GYNECOLOGIC ONCOLOGY, 2006, 102 (02) :309-314

[4] Gallic acid, a major component of Toona sinensis leaf extracts, contains a ROS-mediated anti-cancer activity in human prostate cancer cells [J].

Chen, Huei-Mei ;

Wu, Yang-Chang ;

Chia, Yi-Chen ;

Chang, Fang-Rong ;

Hsu, Hseng-Kuang ;

Hsieh, Ya-Ching ;

Chen, Chih-Chen ;

Yuan, Shyng-Shiou .

CANCER LETTERS, 2009, 286 (02) :161-171

[5] The inhibitory effects of 12 medicinal plants and their component compounds on lipid peroxidation [J].

Cho, EJ ;

Yokozawa, T ;

Rhyu, DY ;

Kim, HY ;

Shibahara, N ;

Park, JC .

AMERICAN JOURNAL OF CHINESE MEDICINE, 2003, 31 (06) :907-917

[6] Study on the inhibitory effects of Korean medicinal plants and their main compounds on the 1,1-diphenyl-2-picrylhydrazyl radical [J].

Cho, EJ ;

Yokozawa, T ;

Rhyu, DY ;

Kim, SC ;

Shibahara, N ;

Park, JC .

PHYTOMEDICINE, 2003, 10 (6-7) :544-551

[7] Evolution of science-based uncertainty factors in noncancer risk assessment [J].

Dourson, ML ;

Felter, SP ;

Robinson, D .

REGULATORY TOXICOLOGY AND PHARMACOLOGY, 1996, 24 (02) :108-120

[8]

Edmonds Jennifer M., 1998, Curtis's Botanical Magazine, V15, P186, DOI 10.1111/1467-8748.00169

[9] Toona sinensis Roem (Meliaceae) leaf extract alleviates liver fibrosis via reducing TGFPI and collagen [J].

Fan, Sabrina ;

Chen, Huan-Nan ;

Wang, Chen-Jhe ;

Tseng, Wei-Chung ;

Hsu, Hseng-Kuang ;

Weng, Ching-Feng .

FOOD AND CHEMICAL TOXICOLOGY, 2007, 45 (11) :2228-2236

[10] Metabolism of phytol to phytanic acid in the mouse, and the role of PPARα in its regulation [J].

Gloerich, J. ;

van den Brink, D. M. ;

Ruiter, J. P. N. ;

van Vlies, N. ;

Vaz, F. M. ;

Wanders, R. J. A. ;

Ferdinandusse, S. .

JOURNAL OF LIPID RESEARCH, 2007, 48 (01) :77-85

← 1 2 3 4 5 →