Glomerular hyperfiltration and albuminuria in critically ill patients

被引:87
作者
Fuster-Lluch, O. [1 ]
Geronimo-Pardo, M.
Peyro-Garcia, R.
Lizan-Garcia, M. [2 ]
机构
[1] Complejo Hosp Univ Albacete, Lab Clin Anal, Dept Clin Anal, Albacete 02006, Spain
[2] Complejo Hosp Univ Albacete, Dept Prevent Med, Albacete 02006, Spain
关键词
glomerular filtration rate; creatinine clearance; albuminuria; proteinuria; intensive care; critical care;
D O I
10.1177/0310057X0803600507
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Glomerular hyperfiltration and albuminuria are two pathological conditions that could alter renal drug elimination, but they have been rarely studied in a critical care setting. The aims of this descriptive, prospective study performed on 89 critically ill patients are to determine rates of glomerular hyperfiltration (main objective) and albuminuria (secondary objective). On admission, 17.9% of patients presented with glomerular hyperfiltration, climbing to rates as high as 30% during the first week of admission. Seventy-five percent showed albuminuria on admission, with rates remaining high throughout the week of the study. Since glomerular hyperfiltration as well as albuminuria are frequent pathophysiological conditions in critical care patients, the implications that these phenomena may have regarding drug elimination need further evaluation.
引用
收藏
页码:674 / 680
页数:7
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